2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAlleles
2018
Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology
Grothe M, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel S, Initiative A. Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology. Brain 2018, 141: 2755-2771. PMID: 30016411, PMCID: PMC6113636, DOI: 10.1093/brain/awy189.Peer-Reviewed Original ResearchConceptsRegional gene expression profilesGene expression profilesAlzheimer's disease pathologyExpression profilesPathophysiological mechanism of Alzheimer's diseaseDisease pathologyAlzheimer's diseaseAmyloid depositsExpression levelsMechanisms of Alzheimer's diseaseHuman brain transcriptomeGene set enrichment analysisTau kinasesAlzheimer's Disease Neuroimaging InitiativeMicroarray measurementsTau proteinMAPT expressionAllen Brain AtlasGene setsAmyloid precursorBrain transcriptomeRas-ERKNeurofibrillary degenerationRegionally selective vulnerabilityMitochondrial respiration