Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease
Guzmán-Vélez E, Diez I, Schoemaker D, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller J, Baena A, Sperling R, Johnson K, Lopera F, Sepulcre J, Quiroz Y. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2113641119. PMID: 35380901, PMCID: PMC9169643, DOI: 10.1073/pnas.2113641119.Peer-Reviewed Original ResearchConceptsDefault-mode networkFunctional connectivitySalience networkRetrospenial cortexFunctional segregationPosterior default-mode networkAmyloid-bDefault-mode network regionsHigher-order cognitive functionsEarly-onset AD dementiaTau pathologyMedial prefrontal cortexAnterior cingulate cortexDisrupting neural communicationGraph-based network analysisBrain functional architectureMedial temporal regionsFunctional networksAlzheimer's diseaseBrain functional connectivityPreclinical Alzheimer's diseasePrefrontal cortexTau burdenCingulate cortexEpisodic memory