2017
Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders
Perez D, Matin N, Barsky A, Costumero-Ramos V, Makaretz S, Young S, Sepulcre J, LaFrance W, Keshavan M, Dickerson B. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. Journal Of Neurology Neurosurgery & Psychiatry 2017, 88: 491. PMID: 28416565, PMCID: PMC5497745, DOI: 10.1136/jnnp-2016-314998.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexChildChild AbuseConversion DisorderDominance, CerebralFemaleGray MatterGyrus CinguliHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalLife Change EventsMagnetic Resonance ImagingMaleMiddle AgedNervous System DiseasesOrgan SizePsychophysiologic DisordersStatistics as TopicStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional neurological symptomsFunctional neurological disorderAnterior cingulate cortexSelf-report measuresInsular volumeChildhood abuseVolumetric associationsSymptom severityPost-traumatic stress disorder symptom severityAssociated with left hippocampal volumeAdverse early-life eventsFunctional neurological disorder patientsLeft hippocampal volumeAdverse life eventsPatient Health Questionnaire-15Neurological symptom severityEarly-life eventsACC volumeDisorder subscaleGender-specific effectsCingulate cortexStress disorderHippocampal volume
2009
Fractal dimension analysis of grey matter in multiple sclerosis
Esteban F, Sepulcre J, de Miras J, Navas J, de Mendizábal N, Goñi J, Quesada J, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. Journal Of The Neurological Sciences 2009, 282: 67-71. PMID: 19167728, DOI: 10.1016/j.jns.2008.12.023.Peer-Reviewed Original ResearchConceptsGray matterMagnetic resonance imagingMultiple sclerosisVoxel-based morphometry approachExtensive grey matterAttack of MST1 MRI sequencesT2 lesion loadShorter disease durationWhite matter abnormalitiesGM abnormalitiesMorphometry approachGM morphologyGM atrophyMeasures of GMLong-term disabilityDisease durationHealthy controlsHuman brainMS patientsLesion loadPatientsAbnormalitiesResonance imagingMRI sequences