2009
Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis
Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal 2009, 15: 509-516. PMID: 19282416, DOI: 10.1177/1352458508101321.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersDisability EvaluationElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleMemoryMiddle AgedMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingNeuropsychological TestsConceptsCognitive impairmentBrain synchronyBRB-NCognitive functionBRB-N scoresEffect of MS lesionsEfficient cognitive processingBrain oscillatory activityHealthy controlsCentral nervous systemWhite matter tractsLong white matter tractsAuditory amplitude modulationExecutive functionVerbal memoryCognitive performanceDistant cortical areasBrain networksCognitive processesMultiple sclerosisBrain synchronizationYears of disease evolutionAuditory stimuliCortical areasBrain damageFatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways
Sepulcre J, Masdeu J, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, Villoslada P. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Multiple Sclerosis Journal 2009, 15: 337-344. PMID: 18987107, DOI: 10.1177/1352458508098373.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrophyFatigueFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingNeural PathwaysNeuropsychological TestsParietal LobeConceptsMultiple sclerosisGray matter atrophyWhite matter lesion locationFatigue scoresLocation of white matter lesionsModified Fatigue Impact ScaleWhite matter lesionsMagnetic resonance imagingVoxel-based morphometry methodFatigue Impact ScaleAtrophy degreeWhite matter regionsMS-related fatigueBilateral middle frontal gyriSymptoms of fatigueLeft superior frontal gyrusLesion loadCognitive/attentional processesPatients' qualityLesion locationResonance imagingSuperior frontal gyrusImpact ScaleLesionsMiddle frontal gyri
2006
Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study
Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle G, Miller D, Thompson A. Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study. JAMA Neurology 2006, 63: 1175-1180. PMID: 16908748, DOI: 10.1001/archneur.63.8.1175.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrophyCerebral CortexCross-Sectional StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedMultiple Sclerosis, Chronic ProgressiveConceptsPrimary progressive MSMultiple sclerosisBilateral thalamic atrophyYears of follow-upPrimary progressive multiple sclerosisYears of symptom onsetHealthy control subjectsGray matterProgressive multiple sclerosisDecreased GM volumeGradient-recalled echo sequenceMagnetic resonance imagingInfratentorial atrophyCross-sectional studyVoxel-based morphometric analysisInfratentorial areaDeep GMThalamic atrophyComparing patientsControl subjectsFollow-upProgressive MSSymptom onsetGray matter atrophyLesion load