2024
Cortical hubs of highly superior autobiographical memory
Orwig W, Diez I, Bueichekú E, Pedale T, Parente F, Campolongo P, Schacter D, Sepulcre J, Santangelo V. Cortical hubs of highly superior autobiographical memory. Cortex 2024, 179: 14-24. PMID: 39094240, DOI: 10.1016/j.cortex.2024.06.018.Peer-Reviewed Original ResearchConceptsSuperior autobiographical memoryAutobiographical memoryCortical hubsWhole-brain connectivity analysisPattern of increased connectivityResting-state fMRI dataWhole-brain analysisAutobiographical memory networkPosterior cingulate cortexMidline areaSeed-based analysisFunctional brain connectivityGraph theory analysisCingulate cortexNeural underpinningsNeuroimaging studiesEnhance memoryRemembering eventsBrain regionsControl participantsConnectivity analysisFMRI dataBrain connectivityCortical regionsWhole-brainTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Diez I, Ortiz-Terán L, Ng T, Albers M, Marshall G, Orwig W, Kim C, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs H, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nature Communications 2024, 15: 4809. PMID: 38844444, PMCID: PMC11156945, DOI: 10.1038/s41467-024-48462-3.Peer-Reviewed Original ResearchConceptsOlfactory systemMedial temporal lobe structuresCognitively normal older adultsOlfactory pathwayOdor identification deficitsNormal older adultsTemporal lobe structuresTau accumulationAlzheimer's diseaseIdentification deficitsGenetic vulnerabilityLobe structuresCortical systemsOlfactory circuitsAssociated with tau accumulationIdentification measuresCortical neurodegenerationOlder adultsPiB-PETTau propagationTau progressionPathological aggregationGenetic backgroundDiffusion MRIPredictive powerA late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study
Beucke J, Diez I, Sepulcre J, Mundorf A, Kaufmann C, Orr S, Pitman R, Shin L. A late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study. Journal Of Psychiatric Research 2024, 171: 230-237. PMID: 38316103, PMCID: PMC11113072, DOI: 10.1016/j.jpsychires.2024.01.032.Peer-Reviewed Original ResearchConceptsAmygdalar responsesCombat exposureCombat stressSymptoms of post-traumatic stress disorderPost-traumatic stress disorderTermination of stress exposureCombat-exposed veteransDiscordant twin studiesImpact brain functionAmygdalar functionStress disorderStress exposureAcute stressTwin studiesTwin pairsCombat experienceNeurogenetic mechanismsBrain functionEarly adulthoodEffects of ageConfounding effects of ageTwin siblingsVeteransPsychosocial evidenceGene expression
2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAllelesLocal Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
Marcos-Vidal L, Martínez-García M, Blas D, Navas-Sánchez F, Pretus C, Ramos-Quiroga J, Richarte V, Vilarroya Ó, Sepulcre J, Desco M, Carmona S. Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults. Journal Of Attention Disorders 2022, 26: 1563-1575. PMID: 35947490, DOI: 10.1177/10870547211031998.Peer-Reviewed Original ResearchConceptsIncreased local connectivityFunctional connectivityAtypical functional connectivity patternsAssociations with symptom severity scoresDistant functional connectivityDistribution of functional connectivityLocal functional connectivityFunctional connectivity patternsDecreased local connectivityADHD sampleNeuroimaging studiesAdult samplesDeficient integrationADHDSymptom severity scoresChild sampleInterference hypothesisLocal connectivityDelay hypothesisDMNConnectivity patternsHealthy controlsDistant connectionsAdultsDistant distributionNetwork Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes
Montal V, Diez I, Kim C, Orwig W, Bueichekú E, Gutiérrez-Zúñiga R, Bejanin A, Pegueroles J, Dols-Icardo O, Vannini P, El-Fakhri G, Johnson K, Sperling R, Fortea J, Sepulcre J. Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes. Science Translational Medicine 2022, 14: eabn7273. PMID: 35895837, PMCID: PMC9942690, DOI: 10.1126/scitranslmed.abn7273.Peer-Reviewed Original ResearchConceptsTau spreadingIntracellular accumulation of tau proteinAccumulation of tau proteinAlzheimer's diseasePathological tau accumulationGenetic gradientGenetic dataTau proteinNeurofibrillary tanglesSynaptic genesTau accumulationGenetic traitsGenesDrug development strategiesExpression gradientIntracellular accumulationTauExpressionCognitively normal older participantsHuman brain cortexTanglesProteinApoTraitsAlzheimerLocal Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
Marcos-Vidal L, Martínez-García M, de Blas D, Navas-Sánchez F, Pretus C, Ramos-Quiroga J, Richarte V, Vilarroya Ó, Sepulcre J, Desco M, Carmona S. Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults. Journal Of Attention Disorders 2022, 26: 1788-1801. PMID: 35684934, DOI: 10.1177/10870547221101646.Peer-Reviewed Original ResearchConceptsIncreased local connectivityFunctional connectivityAtypical functional connectivity patternsAssociations with symptom severity scoresDistant functional connectivityDistribution of functional connectivityLocal functional connectivityFunctional connectivity patternsDecreased local connectivityADHD sampleNeuroimaging studiesAdult samplesDeficient integrationADHDSymptom severity scoresChild sampleInterference hypothesisLocal connectivityDelay hypothesisDMNConnectivity patternsHealthy controlsDistant connectionsAdultsDistant distributionAmyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease
Guzmán-Vélez E, Diez I, Schoemaker D, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller J, Baena A, Sperling R, Johnson K, Lopera F, Sepulcre J, Quiroz Y. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2113641119. PMID: 35380901, PMCID: PMC9169643, DOI: 10.1073/pnas.2113641119.Peer-Reviewed Original ResearchConceptsDefault-mode networkFunctional connectivitySalience networkRetrospenial cortexFunctional segregationPosterior default-mode networkAmyloid-bDefault-mode network regionsHigher-order cognitive functionsEarly-onset AD dementiaTau pathologyMedial prefrontal cortexAnterior cingulate cortexDisrupting neural communicationGraph-based network analysisBrain functional architectureMedial temporal regionsFunctional networksAlzheimer's diseaseBrain functional connectivityPreclinical Alzheimer's diseasePrefrontal cortexTau burdenCingulate cortexEpisodic memoryConnectomic-genetic signatures in the cerebral small vessel disease
Gutiérrez-Zúñiga R, Diez I, Bueichekú E, Kim C, Orwig W, Montal V, Fuentes B, Díez-Tejedor E, Fernández M, Sepulcre J. Connectomic-genetic signatures in the cerebral small vessel disease. Neurobiology Of Disease 2022, 167: 105671. PMID: 35231560, PMCID: PMC8957615, DOI: 10.1016/j.nbd.2022.105671.Peer-Reviewed Original ResearchNeurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease
Basaia S, Agosta F, Diez I, Bueichekú E, Uquillas F, Delgado-Alvarado M, Caballero-Gaudes C, Rodriguez-Oroz M, Stojkovic T, Kostic V, Filippi M, Sepulcre J. Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease. NeuroImage Clinical 2022, 33: 102941. PMID: 35091253, PMCID: PMC8800137, DOI: 10.1016/j.nicl.2022.102941.Peer-Reviewed Original ResearchConceptsParkinson's diseaseBrain circuitsGene expression patternsBrain connectivityPD-related pathologyPD participantsHuman brainHuman cortexTopological intersectionConnectivity networksCortical propagation patternsPostmortem dataGenetic traitsBrainExpression patternsSNCA geneConnectivity trajectoriesGenesCellular componentsNeuronal damageNeuronal vulnerabilityVulnerabilityParkinsonTraits
2021
College education as a modulator of the aging brain
Sepulcre J. College education as a modulator of the aging brain. Nature Aging 2021, 1: 980-981. PMID: 37118340, DOI: 10.1038/s43587-021-00131-6.Peer-Reviewed Original ResearchDivergent connectomic organization delineates genetic evolutionary traits in the human brain
Bueichekú E, Gonzalez-de-Echavarri J, Ortiz-Teran L, Montal V, d’Oleire Uquillas F, De Marcos L, Orwig W, Kim C, Ortiz-Teran E, Basaia S, Diez I, Sepulcre J. Divergent connectomic organization delineates genetic evolutionary traits in the human brain. Scientific Reports 2021, 11: 19692. PMID: 34608211, PMCID: PMC8490416, DOI: 10.1038/s41598-021-99082-6.Peer-Reviewed Original ResearchConceptsEvolutionary traitsHomo sapiens lineageDN/dS ratiosPositive selectionCellular functionsEvolutionary pathwaysGene expressionGenetic expressionSapiens lineageBiological dataCo-localizationDivergent pathwaysFunctional specializationTraitsBiological qualityResting-state dataPathwayHuman brain functionSimian ancestorsExpressionConnectome organizationCognitive trajectoriesAncestorLineagesBrain functionNeurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities
Leaston J, Ferris C, Kulkarni P, Chandramohan D, van de Ven A, Qiao J, Timms L, Sepulcre J, Fakhri G, Ma C, Normandin M, Gharagouzloo C. Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. PLOS ONE 2021, 16: e0256749. PMID: 34449808, PMCID: PMC8396782, DOI: 10.1371/journal.pone.0256749.Peer-Reviewed Original ResearchConceptsVascular abnormalitiesAPOE-e4Contrast-enhanced magnetic resonance imagingBlood-brain-barrier leakageNeurovascular dysfunctionSmall vessel abnormalitiesMagnetic resonance imagingTri-synaptic circuitBlood-brain-barrierCross-sectional studyFemale ratsSignificant signal increaseHyper-vascularizationCerebrovascular abnormalitiesVessel abnormalitiesNeurovascular imagingQUTE-CEBrain volumeAnimal modelsPathological causesAbnormalitiesHistological validationImaging modalitiesResonance imagingA reachable probability approach for the analysis of spatio-temporal dynamics in the human functional network
Gao Q, Xiang Y, Zhang J, Luo N, Liang M, Gong L, Yu J, Cui Q, Sepulcre J, Chen H. A reachable probability approach for the analysis of spatio-temporal dynamics in the human functional network. NeuroImage 2021, 243: 118497. PMID: 34428571, DOI: 10.1016/j.neuroimage.2021.118497.Peer-Reviewed Original ResearchConceptsHuman brainBrain network systemsBrain functional systemsHierarchical functional organizationPrimary sensory cortexHuman functional networkMode networkMultisensory integration regionsPerceptual modalitiesMultisensory integrationSensory cortexNetwork systemAnalysis of spatio-temporal dynamicsFunctional networksTransition probabilitiesNeuronal circuitsDynamic architectureFunctional systemsFunctional organizationLocalize functional regionsDifferential patternConnectional organizationConnection structureProbability approachNetwork steady stateDistance disintegration characterizes node‐level topological dysfunctions in cocaine addiction
Costumero V, Negre P, Bustamante J, Fuentes‐Claramonte P, Adrián‐Ventura J, Palomar‐García M, Miró‐Padilla A, Llopis J, Sepulcre J, Barrós‐Loscertales A. Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction. Addiction Biology 2021, 26: e13072. PMID: 34137121, DOI: 10.1111/adb.13072.Peer-Reviewed Original ResearchConceptsCocaine use disorderFunctional magnetic resonance imagingLateral orbitofrontal cortexGraph theory measuresOrbitofrontal cortexCocaine use disorder individualsRight lateral orbitofrontal cortexResting state functional magnetic resonance imagingMiddle frontal cortexRight temporal poleLength of abstinenceSeverity of dependenceRight rolandic operculumHealthy controlsYears of educationVentral striatumIntellectual functioningLeft insulaLeft hippocampusFrontal cortexRolandic operculumTemporal poleTemporal cortexUse disorderNodal efficiencyCompressed sensorimotor-to-transmodal hierarchical organization in schizophrenia
Dong D, Yao D, Wang Y, Hong S, Genon S, Xin F, Jung K, He H, Chang X, Duan M, Bernhardt B, Margulies D, Sepulcre J, Eickhoff S, Luo C. Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia. Psychological Medicine 2021, 53: 771-784. PMID: 34100349, DOI: 10.1017/s0033291721002129.Peer-Reviewed Original ResearchConceptsCognitive functionBottom-up sensory informationVentral attention regionsExecutive brain regionsExecutive control processesCharacteristics of schizophreniaFrontal-parietal regionsSensory processing deficitsResting-state fMRIImpaired sensory processingSomatosensory-motor systemHypo-connectivityConnectome gradientProcessing deficitsHierarchy organizationTransmodal networksFronto-parietalAttentional demandsBrain areasBrain regionsSchizophreniaMacroscale hierarchySensorimotor regionsHyper-connectivityAffective integrationConnectivity adaptations in dopaminergic systems define the brain maturity of investors
Ortiz-Teran E, Diez I, Sepulcre J, Lopez-Pascual J, Ortiz T. Connectivity adaptations in dopaminergic systems define the brain maturity of investors. Scientific Reports 2021, 11: 11671. PMID: 34083626, PMCID: PMC8175592, DOI: 10.1038/s41598-021-91227-x.Peer-Reviewed Original ResearchConceptsSenior investorsGray matter volumeDopamine-related pathwaysInvestment decisionsStructural brain connectivityBodily stress responsesFinancial tradingReward processingDopaminergic systemInvestorsMatter volumeBrain connectivityBrain maturationAssociated with adrenalineBodily awarenessBrain anatomyWork experienceHuman brainInvestmentBrainNoradrenaline biosynthesisStress responseConnectivity adaptationTranscriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration
Jimenez‐Marin A, Diez I, Labayru G, Sistiaga A, Caballero M, Andres‐Benito P, Sepulcre J, Ferrer I, de Munain A, Cortes J. Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration. Neuropathology And Applied Neurobiology 2021, 47: 1092-1108. PMID: 33955002, PMCID: PMC9292638, DOI: 10.1111/nan.12725.Peer-Reviewed Original ResearchConceptsMicrotubule-associated protein tauAllen Human Brain AtlasRNA analysisSynaptic vesicle recyclingSynaptic vesicle genesHypothesis-driven genesGene clusterDopamine neurotransmitter pathwaysVesicle recyclingProtein tauTranscriptome mapTranscriptome interactionsTau pathologyMyotonic dystrophy type IBrain degenerationBiological processesGenesHuman Brain AtlasAlzheimer's diseaseTranscriptional signatureNeurobiological mechanismsCognitive functionAlpha-synucleinNeurotransmitter pathwaysRNAUnveiling the neuroimaging-genetic intersections in the human brain
Diez I, Sepulcre J. Unveiling the neuroimaging-genetic intersections in the human brain. Current Opinion In Neurology 2021, 34: 480-487. PMID: 34227572, PMCID: PMC8265485, DOI: 10.1097/wco.0000000000000952.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomic dataExpression of genesFunctional annotationGenetic networksGenetic dataTranscriptome dataTranscriptomic datasetsBrain genesGenesBrain phenotypesBrain expressionBiological mechanismsNeuroimaging workNeuroimaging mapsBrain-wideNeuroimaging findingsLife spanExpressionTranscriptomeHuman brainNeuroimagingNetwork interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging
Kim C, Montal V, Diez I, Orwig W, Initiative A, Sepulcre J. Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging. Human Brain Mapping 2021, 42: 2990-3004. PMID: 33955621, PMCID: PMC8193537, DOI: 10.1002/hbm.25350.Peer-Reviewed Original ResearchConceptsCognitively normal older adultsAmyloid-betaPathological hallmarks of Alzheimer's diseaseHallmarks of Alzheimer's diseaseTau depositionPositron emission tomographyGeneral cognitive impairmentTau neurofibrillary tanglesAlzheimer's diseaseNormal older adultsOlder adultsAmyloid-beta depositionCognitive test scoresTau pathogenesisAD vulnerable areasNeurofibrillary tanglesHeteromodal areasTau accumulationCognitive changesCognitive deteriorationCognitive impairmentCognitive declinePathological hallmarkPreclinical ADCognitive level