Memantine induces reversible neurologic impairment in patients with MSSYMBOLSYMBOL
Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J. Memantine induces reversible neurologic impairment in patients with MSSYMBOLSYMBOL. Neurology 2008, 72: 1630-1633. PMID: 19092106, DOI: 10.1212/01.wnl.0000342388.73185.80.Peer-Reviewed Original ResearchMeSH KeywordsBrainCognition DisordersCross-Over StudiesDisability EvaluationDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleExcitatory Amino Acid AntagonistsHumansIatrogenic DiseaseMemantineMultiple Sclerosis, Relapsing-RemittingNeuropsychological TestsPlacebosQuality of LifeSecondary PreventionSeverity of Illness IndexTreatment FailureConceptsQuality of lifeCognitive impairmentCognitive domainsBrief Repeatable Battery-NeuropsychologyIncreased muscle weaknessImprove cognitive performanceMultiple sclerosisNeurological symptomsBaseline disabilityWalking difficultiesUnstable gaitVerbal memoryCognitive performanceCognitive dysfunctionStopping medicationPilot trialNormative dataWorsening of neurological symptomsImpair patients' qualityReverse neurologic impairmentPatients' qualityMuscle weaknessMemantineMemantine armDouble-blind