2019
Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1
Labayru G, Diez I, Sepulcre J, Fernández E, Zulaica M, Cortés J, de Munain A, Sistiaga A. Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1. NeuroImage Clinical 2019, 24: 102078. PMID: 31795042, PMCID: PMC6861566, DOI: 10.1016/j.nicl.2019.102078.Peer-Reviewed Original ResearchConceptsGlobal gray matterDiffusion tensor imagingCTG expansion sizeSubcortical regionsWhite matter lesionsMyotonic dystrophy type 1Fractional anisotropyStructural brain signaturesBrain atrophyAssociated with cognitive impairmentStructural cerebral changesAssociation cortical regionsDegree of muscular impairmentMicrostructural WM abnormalitiesVoxel Based MorphometryWhite matterHealthy controlsDM1 patientsRegional brain atrophyType 1Global white matterIQ estimatesNeuropsychological profileGM reductionNeuropsychological scoresCorticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder
Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina J, Dickerson B, Keshavan M, LaFrance W, Sepulcre J, Perez D. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. Journal Of Neurology Neurosurgery & Psychiatry 2019, 90: 929. PMID: 30850473, PMCID: PMC6625895, DOI: 10.1136/jnnp-2018-319657.Peer-Reviewed Original ResearchConceptsFunctional neurological disorderLeft anterior insulaRight anterior insulaAnterior insulaSymptom severityWithin-group analysisPathophysiology of functional neurological disorderFunctional neurological disorder cohortsMotor functional neurological disorderRight laterobasal amygdalaMultimodal integration networkBilateral posterior insulaMiddle cingulate cortexMultimodal integration areasLaterobasal amygdalaDisorder subscaleCentromedial amygdalaCingulate cortexInteroceptive processingAffective disturbancesPatient-reported symptom severityPosterior insulaWithin-group associationsAmygdalar nucleiBetween-group differences
2018
Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder
Marcos‐Vidal L, Martínez‐García M, Pretus C, Garcia‐Garcia D, Martínez K, Janssen J, Vilarroya O, Castellanos F, Desco M, Sepulcre J, Carmona S. Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder. Human Brain Mapping 2018, 39: 2442-2454. PMID: 29473262, PMCID: PMC6866394, DOI: 10.1002/hbm.24013.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderND childrenFunctional connectivityAttention-deficit/hyperactivityFronto-parietalGroup differencesSomatomotor areasAttention-deficit/hyperactivity disorder symptomsSeverity of ADHD symptomsAttention-deficit/hyperactivity disorder diagnosisAtypical functional connectivityMaturational lag hypothesisVentral attention networkAtypical developmental patternPotential group differencesIncreased local connectivityFunctional networksHuman brain changesMultiple brain regionsLocal functional connectivityImmature functional stateBrain functional networksSeverity of clinical symptomsADHD symptomsSomatomotor regions
2017
Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level.
Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple G. Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level. Revista De Neurologia 2017, 64: 97-104. PMID: 28128426, DOI: 10.33588/rn.6403.2016211.Peer-Reviewed Original ResearchConceptsNeuropsychological batteryTasks measuring working memoryNormative dataOriginal normative sampleInformation processing speedIdentified cognitive impairmentWorking memoryVerbal memoryNeuropsychological assessmentNormative sampleCognitive testsProcessing speedHealthy control groupStandard scoresCognitive impairmentMultiple sclerosisEducation levelHealthy controlsSex variableMemoryTaskHealthy volunteersRegression analysisBatteryControl group
2013
Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Beucke J, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder. JAMA Psychiatry 2013, 70: 619-629. PMID: 23740050, DOI: 10.1001/jamapsychiatry.2013.173.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderOrbitofrontal cortexUnmedicated patientsAntidepressant medicationBasal gangliaSymptom severityObsessive-compulsive disorder symptom severityConsistent with neurobiological modelsTreated with antidepressant medicationResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingOCD symptom severityReduced local connectivityLocal functional connectivityBrain network propertiesDegree connectivityStatistical parametric mappingVentral striatumCase-control cross-sectional studyCorticostriatal circuitryNeurobiological modelsBrain circuitsConnectivity alterations
2011
The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease
Sabuncu M, Desikan R, Sepulcre J, Yeo B, Liu H, Schmansky N, Reuter M, Weiner M, Buckner R, Sperling R, Fischl B, Initiative F. The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease. JAMA Neurology 2011, 68: 1040-1048. PMID: 21825241, PMCID: PMC3248949, DOI: 10.1001/archneurol.2011.167.Peer-Reviewed Original ResearchConceptsMini-Mental State Examination scoreHippocampal volume lossMini-MentalDecreased cognitive performanceCognitive performanceExamination scoresCortical thinningCortical regionsMeasures of cognitive performanceMulticenter case-control studyBaseline hippocampal volumeRate of hippocampal volume lossStudies of neuroimagingMild cognitive impairmentCross-subject analysisAnnual rate of hippocampal volume lossAlzheimer's Disease Neuroimaging InitiativeStudy participantsDementia stagesVolume lossHippocampal volumeIndicators of ADCognitive impairmentHippocampal atrophyLongitudinal atrophy
2007
A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases
Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases. PLOS ONE 2007, 2: e1222. PMID: 18030350, PMCID: PMC2077806, DOI: 10.1371/journal.pone.0001222.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBayes TheoremCalcium-Binding ProteinsCase-Control StudiesEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansImmunotherapyIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLymphocyte ActivationMaleMembrane ProteinsMiceMice, Inbred C57BLMultiple SclerosisReverse Transcriptase Polymerase Chain ReactionSerrate-Jagged ProteinsT-LymphocytesConceptsAutoimmune diseasesMultiple sclerosisTherapeutic targetDevelopment of autoimmune diseasesControlling T cell activationExperimental autoimmune encephalomyelitisT cell proliferationTreatment of miceT cell activationTherapy induced changesLevels similar to controlsIn vitro treatmentGene networksGene interactionsTh1 functionTh2 functionTreg functionImmunomodulatory therapyAutoimmune encephalomyelitisSimilar to controlsIngenuity databaseImmune interventionT cellsDisease courseAgonist peptide
2005
Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis
Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P. Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine 2005, 32: 111-116. PMID: 16246570, DOI: 10.1016/j.cyto.2005.08.005.Peer-Reviewed Original ResearchConceptsCD8+ T cellsRelapsing-remitting MST-cell phenotypeCD8+ lymphocytesDisability scoresIFN-gammaT cellsMultiple sclerosisPeripheral blood T-cell phenotypesPatients treated with interferon-betaHealthy controlsAssociated with disability scoresBlood T-cell phenotypesPeripheral T-cell phenotypePercentage of IFN-gammaEffects of immunomodulatory treatmentsIL-4 producing CD4Decrease of IFN-gammaRelapsing-remitting MS patientsRelapsing-remitting multiple sclerosisPathogenesis of multiple sclerosisCD4+ lymphocytesT cell populationsPresence of IFN-gammaPro-inflammatory profile