2019
Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults
Vannini P, Uquillas F, Jacobs H, Sepulcre J, Gatchel J, Amariglio R, Hanseeuw B, Papp K, Hedden T, Rentz D, Pascual-Leone A, Johnson K, Sperling R. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. NeuroImage Clinical 2019, 24: 102097. PMID: 31795044, PMCID: PMC6879982, DOI: 10.1016/j.nicl.2019.102097.Peer-Reviewed Original ResearchConceptsFeeling-of-knowingEpisodic feeling-of-knowingCognitively unimpaired older adultsMeta-memoryMedial temporal lobe regionsOlder adultsFace-name pairsRegion-of-interest analysisTemporal lobe regionsAlzheimer's diseaseVoxel-wise correlationSemantic knowledge networkTemporal poleLobe regionsEntorhinal cortexNon-famousSensitive clinical indicatorMulti-tracer PETMemory efficiencySemantic informationAdultsTau pathologyAD pathophysiologyParticipantsPET data
2017
Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Sepulcre J, Grothe M, Sabuncu M, Chhatwal J, Schultz A, Hanseeuw B, Fakhri G, Sperling R, Johnson K. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology 2017, 74: 813-820. PMID: 28558094, PMCID: PMC5710537, DOI: 10.1001/jamaneurol.2017.0263.Peer-Reviewed Original ResearchConceptsHeteromodal areasTemporal lobeHarvard Aging Brain StudyHeteromodal association regionsAging Brain StudyCognitively normal participantsElderly brainsPositron emission tomographicPrimary somatomotor cortexDistribution volume ratioAlzheimer's diseaseTau depositionStandardized uptake value ratioVisual regionsNormal participantsAb depositionSomatomotor cortexTemporal areaPittsburgh compound BCarbon 11-labeled Pittsburgh Compound BBrain studiesAssociation regionsHuman brainPathological hallmarks of Alzheimer's diseaseCortical distributionFunctional network integrity presages cognitive decline in preclinical Alzheimer disease
Buckley R, Schultz A, Hedden T, Papp K, Hanseeuw B, Marshall G, Sepulcre J, Smith E, Rentz D, Johnson K, Sperling R, Chhatwal J. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology 2017, 89: 29-37. PMID: 28592457, PMCID: PMC5496516, DOI: 10.1212/wnl.0000000000004059.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer Cognitive CompositePreclinical Alzheimer Cognitive Composite scoreClinically normal older adultsNormal older adultsPreclinical Alzheimer's diseaseRs-fcMRICognitive declineBaseline connectivityResting-state functional connectivity MRIControl networkAD-related cognitive declineMeasures of network integrationFunctional connectivity MRIAlzheimer's diseaseNeuropsychological follow-upControl network connectivityOlder adultsFunctional network integrationCompound B PETPittsburgh compound B PETPredictor of ratingsNetwork integrationDorsal attentionCognitive compositeYears of follow-upFluorodeoxyglucose metabolism associated with tau‐amyloid interaction predicts memory decline
Hanseeuw B, Betensky R, Schultz A, Papp K, Mormino E, Sepulcre J, Bark J, Cosio D, LaPoint M, Chhatwal J, Rentz D, Sperling R, Johnson K. Fluorodeoxyglucose metabolism associated with tau‐amyloid interaction predicts memory decline. Annals Of Neurology 2017, 81: 583-596. PMID: 28253546, PMCID: PMC5404378, DOI: 10.1002/ana.24910.Peer-Reviewed Original ResearchConceptsMemory declineFrontal hypometabolismHarvard Aging Brain StudyAssociated with frontal hypometabolismCourse of preclinical ADAssociated with memory lossAging Brain StudySignificant memory declinePreclinical Alzheimer's diseaseCerebral glucose metabolismAlzheimer's diseaseCingulate metabolismPosterior cingulate metabolismEntorhinal tauEntorhinal cortexPositron emission tomographyPittsburgh compound BPreclinical ADBrain studiesMemory lossImpact of amyloidOlder adultsHypometabolismAge-related tauopathyEmission tomographyTau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchConceptsAging brainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive association
2016
In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain
Sepulcre J, Schultz A, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson K. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. Journal Of Neuroscience 2016, 36: 7364-7374. PMID: 27413148, PMCID: PMC4945661, DOI: 10.1523/jneurosci.0639-16.2016.Peer-Reviewed Original ResearchConceptsHallmarks of AD pathologyAmyloid-bAlzheimer's diseaseAD pathologyHallmarks of Alzheimer's diseaseElderly human brainPositron emission tomographyBrain tissue lossHuman brainTau depositionCortical associationMatter profileCortical mantleGrey matter intensityTauSpatial patternsLocal-to-localTau positron emission tomographyCognitively normal individualsEmission tomographyCognitive symptomsHallmarksTemporal lobeNetwork analysisAssociation areas
2015
Tau positron emission tomographic imaging in aging and early Alzheimer disease
Johnson K, Schultz A, Betensky R, Becker J, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Annals Of Neurology 2015, 79: 110-119. PMID: 26505746, PMCID: PMC4738026, DOI: 10.1002/ana.24546.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCognitive impairmentMild cognitive impairmentClinical impairmentAssociated with clinical impairmentInferior temporal gyrusBrain tau depositionAssociation of cognitive impairmentMild AD dementiaAD dementiaAlzheimer's diseasePositron emission tomographic imagingTau positron emission tomographyTemporal gyrusMonitoring of disease progressionEmission tomographic imagingDisease-modifying therapiesSymptomatic patientsClinically normal individualsPittsburgh compound BControl subjectsDisease progressionClinically normal controlsNormal controlsImpairmentA Spectral Graph Regression Model for Learning Brain Connectivity of Alzheimer’s Disease
Hu C, Cheng L, Sepulcre J, Johnson K, Fakhri G, Lu Y, Li Q. A Spectral Graph Regression Model for Learning Brain Connectivity of Alzheimer’s Disease. PLOS ONE 2015, 10: e0128136. PMID: 26024224, PMCID: PMC4449104, DOI: 10.1371/journal.pone.0128136.Peer-Reviewed Original ResearchConceptsNetwork featuresAlzheimer's diseaseConsistent with known pathologyUnknown graphConnection weightsReconstruction networkCortical hubsDegree statisticsData modelSmooth signalsFeatures of brain pathologyOptimization frameworkAmyloid-bPartial correlation estimationImage dataNetworkGraphGlobal connectivity measuresPositron emission tomographyConnectivity measuresNeurodegenerative diseasesConnectivity patternsSample correlationClinical ADSimulated data
2013
In vivo characterization of the early states of the amyloid-beta network
Sepulcre J, Sabuncu M, Becker A, Sperling R, Johnson K. In vivo characterization of the early states of the amyloid-beta network. Brain 2013, 136: 2239-2252. PMID: 23801740, PMCID: PMC3692037, DOI: 10.1093/brain/awt146.Peer-Reviewed Original ResearchConceptsAmyloid-bAlzheimer's diseasePittsburgh compound B positron emission tomography imagingPrecuneus/posterior cingulate cortexMedial temporal lobeRegional brain atrophyAlzheimer's disease pathologyAmyloid-betaOrbitofrontal cortexCingulate cortexAmygdala nucleiTemporal lobeCortical regionsAssociated with accumulationHub propertiesEmission tomography imagingNeurodegenerative diseasesBrain atrophyDisease pathologyAlzheimerHippocampusAbnormal accumulationCortexIn vivo characterizationElderly subjectsMatched Signal Detection on Graphs: Theory and Application to Brain Network Classification
Hu C, Cheng L, Sepulcre J, El Fakhri G, Lu Y, Li Q. Matched Signal Detection on Graphs: Theory and Application to Brain Network Classification. Lecture Notes In Computer Science 2013, 23: 1-12. PMID: 24683953, DOI: 10.1007/978-3-642-38868-2_1.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlzheimer DiseaseAniline CompoundsBenzothiazolesBrainBrain MappingConnectomeHumansImage EnhancementImage Interpretation, Computer-AssistedNerve NetNeural PathwaysPattern Recognition, AutomatedPositron-Emission TomographyReproducibility of ResultsSensitivity and SpecificityThiazolesTissue DistributionConceptsBrain network classificationNetwork classification problemWeighted energy detectorPrinciple component analysisSub-manifold structureTraditional principle component analysisSubspace detectionTraining dataEnergy detectorGraph structureProblem of Alzheimer's diseaseGraph LaplacianNetwork classificationNoise varianceLevel of smoothnessWeighted graphSignal detectionIntrinsic structureSignal modelGraphSubspaceIsing modelNoiseSignal variationsComponent analysis
2011
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
Drzezga A, Becker J, Van Dijk K, Sreenivasan A, Talukdar T, Sullivan C, Schultz A, Sepulcre J, Putcha D, Greve D, Johnson K, Sperling R. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 2011, 134: 1635-1646. PMID: 21490054, PMCID: PMC3102239, DOI: 10.1093/brain/awr066.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloidAniline CompoundsBenzothiazolesBrain MappingCerebral CortexCognition DisordersFemaleFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenPositron-Emission TomographyStatistics as TopicThiazolesConceptsWhole-brain connectivityDisruption of functional connectivityCortical hubsEarly functional consequencesMild cognitive impairmentFunctional connectivityAmyloid burdenCognitive impairmentNon-demented older individualsVoxel-based morphometry measuresAmyloid-positive patientsStructural magnetic resonanceDisruption of connectivityEmission tomographyCerebral glucose metabolismAlzheimer-type neurodegenerationAssociated with neuronal dysfunctionClinical Alzheimer's diseaseNon-demented subjectsCognitive symptomsIncreased amyloid burdenBrain regionsFunctional disconnectionNeuronal dysfunctionWhole-brain