2023
Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognition
2020
Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade
Labayru G, Jimenez‐Marin A, Fernández E, Villanua J, Zulaica M, Cortes J, Díez I, Sepulcre J, de Munain A, Sistiaga A. Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade. Annals Of Clinical And Translational Neurology 2020, 7: 1802-1815. PMID: 32881379, PMCID: PMC7545612, DOI: 10.1002/acn3.51163.Peer-Reviewed Original ResearchConceptsVoxel Based MorphometryHealthy controlsFronto-subcortical networksPatterns of brain atrophyMultimodal integration networkExecutive function testsBrain structural abnormalitiesRegional brain volumesGM damageDM1 patientsNeuropsychological testsNeurodevelopmental originBrain changesPediatric onset patientsGM lossFrontal regionsVBM analysisWM volumeBrain abnormalitiesBrain volumeCognitive outcomesFollow-up MRI studiesHC groupYoung adulthoodImpairment assessment
2019
Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1
Labayru G, Diez I, Sepulcre J, Fernández E, Zulaica M, Cortés J, de Munain A, Sistiaga A. Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1. NeuroImage Clinical 2019, 24: 102078. PMID: 31795042, PMCID: PMC6861566, DOI: 10.1016/j.nicl.2019.102078.Peer-Reviewed Original ResearchConceptsGlobal gray matterDiffusion tensor imagingCTG expansion sizeSubcortical regionsWhite matter lesionsMyotonic dystrophy type 1Fractional anisotropyStructural brain signaturesBrain atrophyAssociated with cognitive impairmentStructural cerebral changesAssociation cortical regionsDegree of muscular impairmentMicrostructural WM abnormalitiesVoxel Based MorphometryWhite matterHealthy controlsDM1 patientsRegional brain atrophyType 1Global white matterIQ estimatesNeuropsychological profileGM reductionNeuropsychological scores
2017
The association between tau PET and retrospective cortical thinning in clinically normal elderly
LaPoint M, Chhatwal J, Sepulcre J, Johnson K, Sperling R, Schultz A. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage 2017, 157: 612-622. PMID: 28545932, PMCID: PMC5772972, DOI: 10.1016/j.neuroimage.2017.05.049.Peer-Reviewed Original ResearchConceptsTemporal regionsCortical thinningCortical ROIsCortical thicknessRetrospective longitudinal analysisRight temporal regionAssociated with neuronal lossBaseline ageNormal cohortNeuronal lossRate of cortical thinningLeft cuneusPathologyMedial temporal regionsVolumetric ROIsReference regionAtrophyThick cross-sectionsCortical regionsBilateral parahippocampal cortexLongitudinal atrophyLongitudinal analysisLeft superior temporal sulcusCortexBrain studiesAssociation of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease
Xia C, Makaretz S, Caso C, McGinnis S, Gomperts S, Sepulcre J, Gomez-Isla T, Hyman B, Schultz A, Vasdev N, Johnson K, Dickerson B. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurology 2017, 74: 427-436. PMID: 28241163, PMCID: PMC5470368, DOI: 10.1001/jamaneurol.2016.5755.Peer-Reviewed Original ResearchConceptsStructural magnetic resonance imagingAlzheimer's diseaseCortical atrophyHyperphosphorylated tau proteinClinical phenotypeTau in vivoAssociation in vivoAtypical Alzheimer's diseaseMagnetic resonance imagingTau proteinMeasure amyloid burdenPositron emission tomographicNeurofibrillary tanglesMeasure cortical thicknessOutpatient referral centerDisease-modifying therapeuticsTau PET imagingCarbon 11-labeled Pittsburgh Compound BCognitive functionIn vivo evidenceCortical regionsResonance imagingPostmortem studiesCortical thicknessNeurodegenerative diseases
2011
The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease
Sabuncu M, Desikan R, Sepulcre J, Yeo B, Liu H, Schmansky N, Reuter M, Weiner M, Buckner R, Sperling R, Fischl B, Initiative F. The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease. JAMA Neurology 2011, 68: 1040-1048. PMID: 21825241, PMCID: PMC3248949, DOI: 10.1001/archneurol.2011.167.Peer-Reviewed Original ResearchConceptsMini-Mental State Examination scoreHippocampal volume lossMini-MentalDecreased cognitive performanceCognitive performanceExamination scoresCortical thinningCortical regionsMeasures of cognitive performanceMulticenter case-control studyBaseline hippocampal volumeRate of hippocampal volume lossStudies of neuroimagingMild cognitive impairmentCross-subject analysisAnnual rate of hippocampal volume lossAlzheimer's Disease Neuroimaging InitiativeStudy participantsDementia stagesVolume lossHippocampal volumeIndicators of ADCognitive impairmentHippocampal atrophyLongitudinal atrophy
2009
Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway
Sepulcre J, Goñi J, Masdeu J, Bejarano B, de Mendizábal N, Toledo J, Villoslada P. Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway. JAMA Neurology 2009, 66: 173-179. PMID: 19204153, DOI: 10.1001/archneurol.2008.562.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleus atrophyGM atrophyMultiple sclerosisOptic pathway lesionsOptical radiationWhite matterOptic radiation lesionsGray matterWM regionsRegional GM atrophyWhite matter lesionsLesion probability mapsVoxel-based analysisT1 lesionsPathway lesionsLateral geniculate nucleusRadiation lesionsPresence of lesionsMultiple Sclerosis CenterGray matter atrophyOptic pathwayMultiple sclerosis plaquesAtrophyLesionsAxonal injuryFatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways
Sepulcre J, Masdeu J, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, Villoslada P. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Multiple Sclerosis Journal 2009, 15: 337-344. PMID: 18987107, DOI: 10.1177/1352458508098373.Peer-Reviewed Original ResearchConceptsMultiple sclerosisGray matter atrophyWhite matter lesion locationFatigue scoresLocation of white matter lesionsModified Fatigue Impact ScaleWhite matter lesionsMagnetic resonance imagingVoxel-based morphometry methodFatigue Impact ScaleAtrophy degreeWhite matter regionsMS-related fatigueBilateral middle frontal gyriSymptoms of fatigueLeft superior frontal gyrusLesion loadCognitive/attentional processesPatients' qualityLesion locationResonance imagingSuperior frontal gyrusImpact ScaleLesionsMiddle frontal gyri
2008
RETINAL NERVE FIBER LAYER IS ASSOCIATED WITH BRAIN ATROPHY IN MULTIPLE SCLEROSIS
Villoslada P, Sepulcre J, Toledo J, Bejarano B. RETINAL NERVE FIBER LAYER IS ASSOCIATED WITH BRAIN ATROPHY IN MULTIPLE SCLEROSIS. Neurology 2008, 71: 1747-1748. PMID: 19015496, DOI: 10.1212/01.wnl.0000339375.92578.7e.Peer-Reviewed Original ResearchRetinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis
Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Multiple Sclerosis Journal 2008, 14: 906-912. PMID: 18573835, DOI: 10.1177/1352458508090221.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerHeidelberg retinal tomographyOptical coherence tomographyMultiple sclerosisRetinal nerve fiber layer thickness measurementsRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessCompare optical coherence tomographyNerve fiber layer atrophyNerve fiber layerAssociated with physical disabilityRetinal tomographyFiber layerCoherence tomographyAxonal lossNeurological examinationMatched controlsSymbol Digit Modalities TestTissue changesPatientsCognitive disabilitiesAtrophyMS evolutionDetect thinningTomography
2007
Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS
Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology 2007, 68: 1488-1494. PMID: 17470751, DOI: 10.1212/01.wnl.0000260612.51849.ed.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrophyCohort StudiesDisease ProgressionEarly DiagnosisFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisOptic NerveOptic NeuritisPhlebitisPredictive Value of TestsProspective StudiesRetinaRetinal DiseasesRetinal Ganglion CellsRetinal VeinTomography, Optical CoherenceConceptsRetinal nerve fiber layerRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessRetinal periphlebitisOptical coherence tomographyOptic neuritisDisease activityMultiple sclerosisGadolinium-enhancing lesion volumeNerve fiber layer atrophyAssociated with disease activityNerve fiber layerPredicting disease activityExpanded Disability Status ScaleLonger disease durationMatter volumeBaseline MRI studyDisability Status ScaleRetinal evaluationOphthalmologic evaluationWhite matter volumeTemporal quadrantMultiple sclerosis activityRetinal abnormalitiesOCT scans
2006
Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study
Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle G, Miller D, Thompson A. Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study. JAMA Neurology 2006, 63: 1175-1180. PMID: 16908748, DOI: 10.1001/archneur.63.8.1175.Peer-Reviewed Original ResearchConceptsPrimary progressive MSMultiple sclerosisBilateral thalamic atrophyYears of follow-upPrimary progressive multiple sclerosisYears of symptom onsetHealthy control subjectsGray matterProgressive multiple sclerosisDecreased GM volumeGradient-recalled echo sequenceMagnetic resonance imagingInfratentorial atrophyCross-sectional studyVoxel-based morphometric analysisInfratentorial areaDeep GMThalamic atrophyComparing patientsControl subjectsFollow-upProgressive MSSymptom onsetGray matter atrophyLesion load