2023
Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults
Hanseeuw B, Jacobs H, Schultz A, Buckley R, Farrell M, Guehl N, Becker J, Properzi M, Sanchez J, Quiroz Y, Vannini P, Sepulcre J, Yang H, Chhatwal J, Gatchel J, Marshall G, Amariglio R, Papp K, Rentz D, Normandin M, Price J, Healy B, El Fakhri G, Sperling R, Johnson K. Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults. Neurology 2023, 101: e2533-e2544. PMID: 37968130, PMCID: PMC10791053, DOI: 10.1212/wnl.0000000000207962.Peer-Reviewed Original ResearchConceptsAssociated with cognitive declineOlder adultsNon-AD pathologyCognitive declineHippocampal volumeCognitive dataPreclinical Alzheimer Cognitive CompositeInferior temporal tauProspective cohort studyClinically normal older adultsHarvard Aging Brain StudyPittsburgh compound B PET scansOvert cognitive impairmentAnalyzed dataNormal older adultsAging Brain StudyClinically normal adultsLongitudinal associationsAlzheimer's diseaseCohort studyMemory impairmentCognitive compositeCognitive impairmentHippocampal atrophyCognition
2021
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Amariglio R, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Molecular Psychiatry 2021, 26: 7813-7822. PMID: 34588623, PMCID: PMC8873001, DOI: 10.1038/s41380-021-01290-z.Peer-Reviewed Original ResearchConceptsCortical mean diffusivityCognitive declineOlder adultsCognitively normal older adultsHarvard Aging Brain StudyCortical microstructureInferior temporal tauProgression to mild cognitive impairmentNormal older adultsBrain structural changesAmyloid-bAging Brain StudyCompound B PETLongitudinal cognitive declineAD-vulnerable regionsHippocampal atrophy ratesCognitively normal individualsAlzheimer's diseaseMild cognitive impairmentCognitive slopesStructural MRIEntorhinal tauCognitive AssessmentCognitive impairmentLongitudinal cognition
2018
PET staging of amyloidosis using striatum
Hanseeuw B, Betensky R, Mormino E, Schultz A, Sepulcre J, Becker J, Jacobs H, Buckley R, LaPoint M, Vannini P, Donovan N, Chhatwal J, Marshall G, Papp K, Amariglio R, Rentz D, Sperling R, Johnson K, Initiative F, Study A. PET staging of amyloidosis using striatum. Alzheimer's & Dementia 2018, 14: 1281-1292. PMID: 29792874, PMCID: PMC6219621, DOI: 10.1016/j.jalz.2018.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmyloid beta-PeptidesAmyloidosisApolipoprotein E4Brain ConcussionCognitive DysfunctionCorpus StriatumDisease ProgressionFemaleFollow-Up StudiesHumansImage Interpretation, Computer-AssistedLongitudinal StudiesMalePositron-Emission TomographyProspective StudiesSeverity of Illness IndexConceptsPositron emission tomographyHippocampal volumeCortical amyloidInvolvement of cortexPositron emission tomography dataStriatal signalingPositron emission tomography classificationAmyloid positron emission tomographyStriatumCognitive declineCortical measuresCortexPostmortem dataCognitionCortical depositsEmission tomographyIncreased predictive powerDementia progressionAdvanced amyloidosisDementia researchAlzheimerPET dataStriatalFollow-up dataPredictive power
2010
Lexical access changes in patients with multiple sclerosis: A two-year follow-up study
Sepulcre J, Peraita H, Goñi J, Arrondo G, Martincorena I, Duque B, de Mendizábal N, Masdeu J, Villoslada P. Lexical access changes in patients with multiple sclerosis: A two-year follow-up study. Journal Of Clinical And Experimental Neuropsychology 2010, 33: 169-175. PMID: 20835944, DOI: 10.1080/13803395.2010.499354.Peer-Reviewed Original ResearchConceptsConfrontation namingRetrieval of lexical informationSemantic verbal fluency taskPhonemic verbal fluency testVerbal fluency taskVerbal fluency testFluency taskTwo-year follow-up studyFluency testSwitching scoresLexical informationMultiple sclerosisMS patientsCommunication abilityHealthy controlsFollow-up studyNamesImpairmentYear follow-upConfrontationTaskScoresRetrievalSclerosisAbility
2008
Memory decline evolves independently of disease activity in MS
Duque B, Sepulcre J, Bejarano B, Samaranch L, Pastor P, Villoslada P. Memory decline evolves independently of disease activity in MS. Multiple Sclerosis Journal 2008, 14: 947-953. PMID: 18573817, DOI: 10.1177/1352458508089686.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestSymbol Digit Modalities Test performanceCognitive impairmentBrief Repeatable Battery-NeuropsychologyVerbal memory performanceNatural history of cognitive impairmentExecutive functionVerbal memoryMemory performanceMemory declineHistory of cognitive impairmentCognitive evaluationMultiple sclerosisModal testingDisease activityDisability progressionDisabilityImpairmentMemoryEDSS changeStudy entryParameters of disease activityMS patientsProspective cohortRelapse
2007
Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS
Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology 2007, 68: 1488-1494. PMID: 17470751, DOI: 10.1212/01.wnl.0000260612.51849.ed.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrophyCohort StudiesDisease ProgressionEarly DiagnosisFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisOptic NerveOptic NeuritisPhlebitisPredictive Value of TestsProspective StudiesRetinaRetinal DiseasesRetinal Ganglion CellsRetinal VeinTomography, Optical CoherenceConceptsRetinal nerve fiber layerRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessRetinal periphlebitisOptical coherence tomographyOptic neuritisDisease activityMultiple sclerosisGadolinium-enhancing lesion volumeNerve fiber layer atrophyAssociated with disease activityNerve fiber layerPredicting disease activityExpanded Disability Status ScaleLonger disease durationMatter volumeBaseline MRI studyDisability Status ScaleRetinal evaluationOphthalmologic evaluationWhite matter volumeTemporal quadrantMultiple sclerosis activityRetinal abnormalitiesOCT scans