2013
Individual Variability in Functional Connectivity Architecture of the Human Brain
Mueller S, Wang D, Fox M, Yeo B, Sepulcre J, Sabuncu M, Shafee R, Lu J, Liu H. Individual Variability in Functional Connectivity Architecture of the Human Brain. Neuron 2013, 77: 586-595. PMID: 23395382, PMCID: PMC3746075, DOI: 10.1016/j.neuron.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAnimalsBrain MappingCerebral CortexFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedIndividualityMacaca mulattaMagnetic Resonance ImagingMaleMeta-Analysis as TopicMiddle AgedNeural PathwaysOxygenPhotic StimulationPredictive Value of TestsRegression AnalysisTime FactorsConceptsResting-state functional MRIHeteromodal association cortexFunctional connectivity architectureCognitive domainsUnimodal cortexIndividual differencesFunctional MRIFunctional connectivityAssociation cortexConnection variablesLong-range connectivityBrain anatomyCortical thicknessBrain evolutionHuman brainCortexSulcal depthIntersubject variabilityStatistical mapsIndividual variabilityConnectivity architectureBrainFunctional variablesLocal connectivityCortical expansion
2011
Computational classifiers for predicting the short-term course of Multiple sclerosis
Bejarano B, Bianco M, Gonzalez-Moron D, Sepulcre J, Goñi J, Arcocha J, Soto O, Carro U, Comi G, Leocani L, Villoslada P. Computational classifiers for predicting the short-term course of Multiple sclerosis. BMC Neurology 2011, 11: 67. PMID: 21649880, PMCID: PMC3118106, DOI: 10.1186/1471-2377-11-67.Peer-Reviewed Original ResearchConceptsClinical end pointsCentral motor conduction timeMotor evoked potentialsMultiple sclerosisDiagnostic accuracyEnd pointsMRI lesion loadCourse of multiple sclerosisShort-term prognosisCourse of MSPrognosis of multiple sclerosisMotor conduction timeEDSS changeDisability progressionShort-term disabilityProspective cohortDisease courseClinical dataBaseline disabilityShort-term courseClinical variablesIndependent cohortMS patientsGray matter volumeBackgroundThe aim
2009
Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway
Sepulcre J, Goñi J, Masdeu J, Bejarano B, de Mendizábal N, Toledo J, Villoslada P. Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway. JAMA Neurology 2009, 66: 173-179. PMID: 19204153, DOI: 10.1001/archneurol.2008.562.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleus atrophyGM atrophyMultiple sclerosisOptic pathway lesionsOptical radiationWhite matterOptic radiation lesionsGray matterWM regionsRegional GM atrophyWhite matter lesionsLesion probability mapsVoxel-based analysisT1 lesionsPathway lesionsLateral geniculate nucleusRadiation lesionsPresence of lesionsMultiple Sclerosis CenterGray matter atrophyOptic pathwayMultiple sclerosis plaquesAtrophyLesionsAxonal injury
2007
Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS
Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada P. Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology 2007, 68: 1488-1494. PMID: 17470751, DOI: 10.1212/01.wnl.0000260612.51849.ed.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrophyCohort StudiesDisease ProgressionEarly DiagnosisFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisOptic NerveOptic NeuritisPhlebitisPredictive Value of TestsProspective StudiesRetinaRetinal DiseasesRetinal Ganglion CellsRetinal VeinTomography, Optical CoherenceConceptsRetinal nerve fiber layerRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessRetinal periphlebitisOptical coherence tomographyOptic neuritisDisease activityMultiple sclerosisGadolinium-enhancing lesion volumeNerve fiber layer atrophyAssociated with disease activityNerve fiber layerPredicting disease activityExpanded Disability Status ScaleLonger disease durationMatter volumeBaseline MRI studyDisability Status ScaleRetinal evaluationOphthalmologic evaluationWhite matter volumeTemporal quadrantMultiple sclerosis activityRetinal abnormalitiesOCT scans