2017
Functional network integrity presages cognitive decline in preclinical Alzheimer disease
Buckley R, Schultz A, Hedden T, Papp K, Hanseeuw B, Marshall G, Sepulcre J, Smith E, Rentz D, Johnson K, Sperling R, Chhatwal J. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology 2017, 89: 29-37. PMID: 28592457, PMCID: PMC5496516, DOI: 10.1212/wnl.0000000000004059.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer Cognitive CompositePreclinical Alzheimer Cognitive Composite scoreClinically normal older adultsNormal older adultsPreclinical Alzheimer's diseaseRs-fcMRICognitive declineBaseline connectivityResting-state functional connectivity MRIControl networkAD-related cognitive declineMeasures of network integrationFunctional connectivity MRIAlzheimer's diseaseNeuropsychological follow-upControl network connectivityOlder adultsFunctional network integrationCompound B PETPittsburgh compound B PETPredictor of ratingsNetwork integrationDorsal attentionCognitive compositeYears of follow-up
2006
Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study
Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle G, Miller D, Thompson A. Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study. JAMA Neurology 2006, 63: 1175-1180. PMID: 16908748, DOI: 10.1001/archneur.63.8.1175.Peer-Reviewed Original ResearchConceptsPrimary progressive MSMultiple sclerosisBilateral thalamic atrophyYears of follow-upPrimary progressive multiple sclerosisYears of symptom onsetHealthy control subjectsGray matterProgressive multiple sclerosisDecreased GM volumeGradient-recalled echo sequenceMagnetic resonance imagingInfratentorial atrophyCross-sectional studyVoxel-based morphometric analysisInfratentorial areaDeep GMThalamic atrophyComparing patientsControl subjectsFollow-upProgressive MSSymptom onsetGray matter atrophyLesion load