2020
Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity
Orwig W, Diez I, Vannini P, Beaty R, Sepulcre J. Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity. Journal Of Cognitive Neuroscience 2020, 33: 499-509. PMID: 33284079, PMCID: PMC8826533, DOI: 10.1162/jocn_a_01658.Peer-Reviewed Original ResearchConceptsAssociated with lower DTStudies of creative cognitionField of cognitive neuroscienceComputational semantic modelsSample of healthy adultsMeasuring creative performanceLevels of DTRight inferior occipitalFunctional brain networksResting-state networksResting-state imagingSemantic distanceVisual temporalLow DTCognitive neuroscienceNeural basisCreative cognitionGeneration of novel ideasTemporal cortexInferior occipitalBrain networksParietal regionsGray matter voxelsConnectivity decreaseVisual regions
2017
Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Sepulcre J, Grothe M, Sabuncu M, Chhatwal J, Schultz A, Hanseeuw B, Fakhri G, Sperling R, Johnson K. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology 2017, 74: 813-820. PMID: 28558094, PMCID: PMC5710537, DOI: 10.1001/jamaneurol.2017.0263.Peer-Reviewed Original ResearchConceptsHeteromodal areasTemporal lobeHarvard Aging Brain StudyHeteromodal association regionsAging Brain StudyCognitively normal participantsElderly brainsPositron emission tomographicPrimary somatomotor cortexDistribution volume ratioAlzheimer's diseaseTau depositionStandardized uptake value ratioVisual regionsNormal participantsAb depositionSomatomotor cortexTemporal areaPittsburgh compound BCarbon 11-labeled Pittsburgh Compound BBrain studiesAssociation regionsHuman brainPathological hallmarks of Alzheimer's diseaseCortical distribution