2017
Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level.
Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple G. Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level. Revista De Neurologia 2017, 64: 97-104. PMID: 28128426, DOI: 10.33588/rn.6403.2016211.Peer-Reviewed Original ResearchConceptsNeuropsychological batteryTasks measuring working memoryNormative dataOriginal normative sampleInformation processing speedIdentified cognitive impairmentWorking memoryVerbal memoryNeuropsychological assessmentNormative sampleCognitive testsProcessing speedHealthy control groupStandard scoresCognitive impairmentMultiple sclerosisEducation levelHealthy controlsSex variableMemoryTaskHealthy volunteersRegression analysisBatteryControl group
2009
Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis
Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal 2009, 15: 509-516. PMID: 19282416, DOI: 10.1177/1352458508101321.Peer-Reviewed Original ResearchConceptsCognitive impairmentBrain synchronyBRB-NCognitive functionBRB-N scoresEffect of MS lesionsEfficient cognitive processingBrain oscillatory activityHealthy controlsCentral nervous systemWhite matter tractsLong white matter tractsAuditory amplitude modulationExecutive functionVerbal memoryCognitive performanceDistant cortical areasBrain networksCognitive processesMultiple sclerosisBrain synchronizationYears of disease evolutionAuditory stimuliCortical areasBrain damage
2008
Memantine induces reversible neurologic impairment in patients with MSSYMBOLSYMBOL
Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J. Memantine induces reversible neurologic impairment in patients with MSSYMBOLSYMBOL. Neurology 2008, 72: 1630-1633. PMID: 19092106, DOI: 10.1212/01.wnl.0000342388.73185.80.Peer-Reviewed Original ResearchMeSH KeywordsBrainCognition DisordersCross-Over StudiesDisability EvaluationDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleExcitatory Amino Acid AntagonistsHumansIatrogenic DiseaseMemantineMultiple Sclerosis, Relapsing-RemittingNeuropsychological TestsPlacebosQuality of LifeSecondary PreventionSeverity of Illness IndexTreatment FailureConceptsQuality of lifeCognitive impairmentCognitive domainsBrief Repeatable Battery-NeuropsychologyIncreased muscle weaknessImprove cognitive performanceMultiple sclerosisNeurological symptomsBaseline disabilityWalking difficultiesUnstable gaitVerbal memoryCognitive performanceCognitive dysfunctionStopping medicationPilot trialNormative dataWorsening of neurological symptomsImpair patients' qualityReverse neurologic impairmentPatients' qualityMuscle weaknessMemantineMemantine armDouble-blindMapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain
Sepulcre J, Masdeu J, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor M, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. NeuroImage 2008, 42: 1237-1243. PMID: 18585467, DOI: 10.1016/j.neuroimage.2008.05.038.Peer-Reviewed Original ResearchConceptsAnterior temporal stemDeclarative verbal memoryLiving human brainVerbal memoryTemporal stemDisrupted white matter pathwaysVerbal memory processesHuman brainFronto-occipital fasciculusWhite matter pathwaysMemory processesLeft hemisphereBrain pathwaysWhite matter regionsWhite matter lesionsAnterior limbThalamic regionsMemory storageMatter regionsMagnetic resonance imagingBrainInternal capsuleWhite matterMemoryMultiple sclerosis patientsMemory decline evolves independently of disease activity in MS
Duque B, Sepulcre J, Bejarano B, Samaranch L, Pastor P, Villoslada P. Memory decline evolves independently of disease activity in MS. Multiple Sclerosis Journal 2008, 14: 947-953. PMID: 18573817, DOI: 10.1177/1352458508089686.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestSymbol Digit Modalities Test performanceCognitive impairmentBrief Repeatable Battery-NeuropsychologyVerbal memory performanceNatural history of cognitive impairmentExecutive functionVerbal memoryMemory performanceMemory declineHistory of cognitive impairmentCognitive evaluationMultiple sclerosisModal testingDisease activityDisability progressionDisabilityImpairmentMemoryEDSS changeStudy entryParameters of disease activityMS patientsProspective cohortRelapse