2021
Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction
Costumero V, Negre P, Bustamante J, Fuentes‐Claramonte P, Adrián‐Ventura J, Palomar‐García M, Miró‐Padilla A, Llopis J, Sepulcre J, Barrós‐Loscertales A. Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction. Addiction Biology 2021, 26: e13072. PMID: 34137121, DOI: 10.1111/adb.13072.Peer-Reviewed Original ResearchConceptsCocaine use disorderFunctional magnetic resonance imagingLateral orbitofrontal cortexGraph theory measuresOrbitofrontal cortexCocaine use disorder individualsRight lateral orbitofrontal cortexResting state functional magnetic resonance imagingMiddle frontal cortexRight temporal poleLength of abstinenceSeverity of dependenceRight rolandic operculumHealthy controlsYears of educationVentral striatumIntellectual functioningLeft insulaLeft hippocampusFrontal cortexRolandic operculumTemporal poleTemporal cortexUse disorderNodal efficiency
2020
Heightened degree connectivity of the striatum in obsessive-compulsive disorder induced by symptom provocation
Beucke J, Simon D, Sepulcre J, Talukdar T, Feusner J, Kaufmann C, Kathmann N. Heightened degree connectivity of the striatum in obsessive-compulsive disorder induced by symptom provocation. Journal Of Affective Disorders 2020, 276: 1069-1076. PMID: 32768879, DOI: 10.1016/j.jad.2020.07.062.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSymptom provocationPassive viewingMeta-analysis of functional neuroimaging studiesSymptoms of obsessive-compulsive disorderVentral striatum/nucleus accumbensSelf-referential evaluationFunctional neuroimaging studiesNeutral control conditionConcurrent task demandsNeutral picturesStriatum/nucleus accumbensVentral striatumOCD symptomsStriatal subdivisionsDorsal striatumNAc connectivityUnmedicated patientsCorticostriatal areasNeuroimaging evidenceNeuroimaging studiesTask demandsConnectivity differencesNetwork abnormalitiesGroup differences
2013
Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Beucke J, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder. JAMA Psychiatry 2013, 70: 619-629. PMID: 23740050, DOI: 10.1001/jamapsychiatry.2013.173.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderOrbitofrontal cortexUnmedicated patientsAntidepressant medicationBasal gangliaSymptom severityObsessive-compulsive disorder symptom severityConsistent with neurobiological modelsTreated with antidepressant medicationResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingOCD symptom severityReduced local connectivityLocal functional connectivityBrain network propertiesDegree connectivityStatistical parametric mappingVentral striatumCase-control cross-sectional studyCorticostriatal circuitryNeurobiological modelsBrain circuitsConnectivity alterations