Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study
Sepulcre J, Sastre-Garriga J, Cercignani M, Ingle G, Miller D, Thompson A. Regional Gray Matter Atrophy in Early Primary Progressive Multiple Sclerosis: A Voxel-Based Morphometry Study. JAMA Neurology 2006, 63: 1175-1180. PMID: 16908748, DOI: 10.1001/archneur.63.8.1175.Peer-Reviewed Original ResearchConceptsPrimary progressive MSMultiple sclerosisBilateral thalamic atrophyYears of follow-upPrimary progressive multiple sclerosisYears of symptom onsetHealthy control subjectsGray matterProgressive multiple sclerosisDecreased GM volumeGradient-recalled echo sequenceMagnetic resonance imagingInfratentorial atrophyCross-sectional studyVoxel-based morphometric analysisInfratentorial areaDeep GMThalamic atrophyComparing patientsControl subjectsFollow-upProgressive MSSymptom onsetGray matter atrophyLesion load