A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases
Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P. A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases. PLOS ONE 2007, 2: e1222. PMID: 18030350, PMCID: PMC2077806, DOI: 10.1371/journal.pone.0001222.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBayes TheoremCalcium-Binding ProteinsCase-Control StudiesEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansImmunotherapyIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLymphocyte ActivationMaleMembrane ProteinsMiceMice, Inbred C57BLMultiple SclerosisReverse Transcriptase Polymerase Chain ReactionSerrate-Jagged ProteinsT-LymphocytesConceptsAutoimmune diseasesMultiple sclerosisTherapeutic targetDevelopment of autoimmune diseasesControlling T cell activationExperimental autoimmune encephalomyelitisT cell proliferationTreatment of miceT cell activationTherapy induced changesLevels similar to controlsIn vitro treatmentGene networksGene interactionsTh1 functionTh2 functionTreg functionImmunomodulatory therapyAutoimmune encephalomyelitisSimilar to controlsIngenuity databaseImmune interventionT cellsDisease courseAgonist peptide