2020
The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Fortea J, Johnson K, Sperling R, Vannini P. The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.041626.Peer-Reviewed Original ResearchCortical mean diffusivityC-PiB PETTemporo-parietal brain regionsHarvard Aging Brain StudyAmyloid-bAlzheimer's diseaseMean diffusivityPreclinical stage of Alzheimer's diseaseAging Brain StudyGray matterPreclinical Alzheimer's diseaseStages of Alzheimer's diseaseCerebellar gray matterBrain regionsRegions-of-interestTemporal regionsSurface-based approachEntorhinal cortexBrain studiesGlial activationBrain microstructural propertiesLongitudinal studyCortical MDNon-linear trajectoriesCortical microstructure
2017
The association between tau PET and retrospective cortical thinning in clinically normal elderly
LaPoint M, Chhatwal J, Sepulcre J, Johnson K, Sperling R, Schultz A. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage 2017, 157: 612-622. PMID: 28545932, PMCID: PMC5772972, DOI: 10.1016/j.neuroimage.2017.05.049.Peer-Reviewed Original ResearchConceptsTemporal regionsCortical thinningCortical ROIsCortical thicknessRetrospective longitudinal analysisRight temporal regionAssociated with neuronal lossBaseline ageNormal cohortNeuronal lossRate of cortical thinningLeft cuneusPathologyMedial temporal regionsVolumetric ROIsReference regionAtrophyThick cross-sectionsCortical regionsBilateral parahippocampal cortexLongitudinal atrophyLongitudinal analysisLeft superior temporal sulcusCortexBrain studies