2023
Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
Prokopiou P, Engels-Domínguez N, Schultz A, Sepulcre J, Koops E, Papp K, Marshall G, Normandin M, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology 2023, 101: e1206-e1217. PMID: 37491329, PMCID: PMC10516269, DOI: 10.1212/wnl.0000000000207646.Peer-Reviewed Original ResearchConceptsLC activityMemory declineLocus coeruleusCognitive declineEC tauHarvard Aging Brain StudyHuman neuroimaging studiesSteeper memory declineNoradrenergic brainstem nucleiLongitudinal cognitive dataFunctional MRI dataTau depositionAging Brain StudyPreclinical Alzheimer's diseaseTau progressionCortical tau depositionElevated beta-amyloidInterventions promoting resilienceMild cognitive impairmentExecutive dysfunctionExecutive functionNeuroimaging studiesTau spreadingTemporal cortexCognitive composite
2022
Network hub centrality and working memory performance in schizophrenia
Eryilmaz H, Pax M, O’Neill A, Vangel M, Diez I, Holt D, Camprodon J, Sepulcre J, Roffman J. Network hub centrality and working memory performance in schizophrenia. Schizophrenia 2022, 8: 76. PMID: 36151201, PMCID: PMC9508261, DOI: 10.1038/s41537-022-00288-y.Peer-Reviewed Original ResearchWorking memory performanceVentral attention networkMemory performanceRight superior temporal cortexAssociated with poorer performanceAssociated with cognitive performanceWorking memory deficitsAssociated with better performanceWorking memory accuracySuperior temporal cortexBetween-network connectivityBrain network hubsGender-matched healthy controlsGraph theory metricsMemory accuracyMemory deficitsCognitive deficitsCognitive symptomsSustained attentionTemporal cortexCognitive performanceExternal cognitionQuantifying centralityCortical hubsSchizophrenia
2021
Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction
Costumero V, Negre P, Bustamante J, Fuentes‐Claramonte P, Adrián‐Ventura J, Palomar‐García M, Miró‐Padilla A, Llopis J, Sepulcre J, Barrós‐Loscertales A. Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction. Addiction Biology 2021, 26: e13072. PMID: 34137121, DOI: 10.1111/adb.13072.Peer-Reviewed Original ResearchConceptsCocaine use disorderFunctional magnetic resonance imagingLateral orbitofrontal cortexGraph theory measuresOrbitofrontal cortexCocaine use disorder individualsRight lateral orbitofrontal cortexResting state functional magnetic resonance imagingMiddle frontal cortexRight temporal poleLength of abstinenceSeverity of dependenceRight rolandic operculumHealthy controlsYears of educationVentral striatumIntellectual functioningLeft insulaLeft hippocampusFrontal cortexRolandic operculumTemporal poleTemporal cortexUse disorderNodal efficiency
2020
Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity
Orwig W, Diez I, Vannini P, Beaty R, Sepulcre J. Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity. Journal Of Cognitive Neuroscience 2020, 33: 499-509. PMID: 33284079, PMCID: PMC8826533, DOI: 10.1162/jocn_a_01658.Peer-Reviewed Original ResearchConceptsAssociated with lower DTStudies of creative cognitionField of cognitive neuroscienceComputational semantic modelsSample of healthy adultsMeasuring creative performanceLevels of DTRight inferior occipitalFunctional brain networksResting-state networksResting-state imagingSemantic distanceVisual temporalLow DTCognitive neuroscienceNeural basisCreative cognitionGeneration of novel ideasTemporal cortexInferior occipitalBrain networksParietal regionsGray matter voxelsConnectivity decreaseVisual regions