2024
Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Communications Medicine 2024, 4: 65. PMID: 38580832, PMCID: PMC10997795, DOI: 10.1038/s43856-024-00497-9.Peer-Reviewed Original ResearchMemory declineMedial anterior prefrontal cortexAging brainWhole-brain voxel-wiseAnterior prefrontal cortexRegion-of-interest analysisResting-state functional MRIObjective memory declineOccipito-parietal regionsMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksPrefrontal cortexMnemonic anosognosiaTau burdenBiomarkers of AD pathologyMode networkParieto-occipital areasFunctional network connectivity disruptionFunctional MRIBrain phenotypesVoxel-wiseBehavioral conditionsBehavioral biomarkers
2023
Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080294.Peer-Reviewed Original ResearchMnemonic anosognosiaOccipito-parietal regionsMemory declineBrain phenotypesSelf-referential brain networkObjective memory testsObjective memory declineResting-state fMRIPosterior cerebral cortexMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksGraph theory metricsTau burdenNeurocognitive profileBiomarkers of AD pathologyMemory testMemory impairmentBetween-group comparisonsFunctional network connectivity disruptionBrain networksAging brainAnosognosiaBehavioral conditionsRelationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity
Cacciamani F, Gagliardi G, Mimmack K, Qiao K, Bueichekú E, Marshall G, Sepulcre J, Diez I, Vannini P. Relationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079806.Peer-Reviewed Original ResearchAwareness of cognitive declineResting-state functional connectivityLinear regression modelsSelf-referential networkHigher tau burdenFunctional connectivityCognitive declineRegression modelsTau accumulationAlzheimer's diseaseImpaired resting-state functional connectivityAlzheimer's disease spectrumResting-state fMRI dataAssociated with tau accumulationDorsal attention networkReduced awarenessWithin-network connectivityModulatory roleLow awarenessTau burdenEffects of tauCognitive function indicesTau interactionsSalience networkTau pathologyCorrelations between APOE4 status and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 status and regional amyloid and tau burdens in cognitively normal older individuals. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.065023.Peer-Reviewed Original ResearchApolipoprotein epsilon 4Standardized uptake value ratioCarrier statusCortical thicknessPositron emission tomographyApolipoprotein epsilon 4 statusTau burdenCognitively normal older individualsAPOE4 carriersRegional amyloidNon-carriersCross-sectional studyNormal older individualsCognitively normal participantsFlorbetapir positron emission tomographyNormal cognitive functionAPOE4 non-carriersAssociated with amyloid depositionRegional tau burdenCognitive functionAD-related biomarkersAge differencesPhosphorylated tauNormal participantsClinical characteristics
2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAllelesAmyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease
Guzmán-Vélez E, Diez I, Schoemaker D, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller J, Baena A, Sperling R, Johnson K, Lopera F, Sepulcre J, Quiroz Y. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2113641119. PMID: 35380901, PMCID: PMC9169643, DOI: 10.1073/pnas.2113641119.Peer-Reviewed Original ResearchConceptsDefault-mode networkFunctional connectivitySalience networkRetrospenial cortexFunctional segregationPosterior default-mode networkAmyloid-bDefault-mode network regionsHigher-order cognitive functionsEarly-onset AD dementiaTau pathologyMedial prefrontal cortexAnterior cingulate cortexDisrupting neural communicationGraph-based network analysisBrain functional architectureMedial temporal regionsFunctional networksAlzheimer's diseaseBrain functional connectivityPreclinical Alzheimer's diseasePrefrontal cortexTau burdenCingulate cortexEpisodic memory
2021
Amyloid‐β and tau pathologies relate to distinctive brain dysconnectomics in autosomal‐dominant Alzheimer’s disease
Guzman‐Velez E, Diez I, Schoemaker D, Pardilla‐Delgado E, Fox‐Fuller J, Vila‐Castelar C, Baena A, Sperling R, Johnson K, Lopera F, Sepulcre J, Quiroz Y. Amyloid‐β and tau pathologies relate to distinctive brain dysconnectomics in autosomal‐dominant Alzheimer’s disease. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056134.Peer-Reviewed Original ResearchAmyloid-bWeighted-degreesTau pathologyAutosomal-dominant Alzheimer's diseaseNon-carriersAutosomal-dominant ADTau burdenPredicting disease riskTau seedsPresenilin-1Tau propagationPSEN-1AD progressionSignificance thresholdAlzheimer's diseaseTauGraph-based network analysisMutation carriersTau-PETPosterior cingulate cortexMutationsConnectivity mapsGenetically-determinedResting-state fMRINetwork analysis