2021
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities
Leaston J, Ferris C, Kulkarni P, Chandramohan D, van de Ven A, Qiao J, Timms L, Sepulcre J, Fakhri G, Ma C, Normandin M, Gharagouzloo C. Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. PLOS ONE 2021, 16: e0256749. PMID: 34449808, PMCID: PMC8396782, DOI: 10.1371/journal.pone.0256749.Peer-Reviewed Original ResearchConceptsVascular abnormalitiesAPOE-e4Contrast-enhanced magnetic resonance imagingBlood-brain-barrier leakageNeurovascular dysfunctionSmall vessel abnormalitiesMagnetic resonance imagingTri-synaptic circuitBlood-brain-barrierCross-sectional studyFemale ratsSignificant signal increaseHyper-vascularizationCerebrovascular abnormalitiesVessel abnormalitiesNeurovascular imagingQUTE-CEBrain volumeAnimal modelsPathological causesAbnormalitiesHistological validationImaging modalitiesResonance imaging
2017
Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease
Xia C, Makaretz S, Caso C, McGinnis S, Gomperts S, Sepulcre J, Gomez-Isla T, Hyman B, Schultz A, Vasdev N, Johnson K, Dickerson B. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurology 2017, 74: 427-436. PMID: 28241163, PMCID: PMC5470368, DOI: 10.1001/jamaneurol.2016.5755.Peer-Reviewed Original ResearchConceptsStructural magnetic resonance imagingAlzheimer's diseaseCortical atrophyHyperphosphorylated tau proteinClinical phenotypeTau in vivoAssociation in vivoAtypical Alzheimer's diseaseMagnetic resonance imagingTau proteinMeasure amyloid burdenPositron emission tomographicNeurofibrillary tanglesMeasure cortical thicknessOutpatient referral centerDisease-modifying therapeuticsTau PET imagingCarbon 11-labeled Pittsburgh Compound BCognitive functionIn vivo evidenceCortical regionsResonance imagingPostmortem studiesCortical thicknessNeurodegenerative diseases
2016
Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications
Teipel S, Grothe M, Zhou J, Sepulcre J, Dyrba M, Sorg C, Babiloni C. Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications. Journal Of The International Neuropsychological Society 2016, 22: 138-163. PMID: 26888613, DOI: 10.1017/s1355617715000995.Peer-Reviewed Original ResearchConceptsCortical connectivityMild cognitive impairmentClinical applicationFunctional cortical connectivityMagnetic resonance imagingWhite matter bundlesResting-state functional magnetic resonance imagingDiffusion tensor imagingBlood oxygen level-dependent activityPre-clinicalEEG rhythmsCerebral reserve capacityResonance imagingNetwork pathologyAttention-related networksIn vivoMild AD dementia patientsTensor imagingBrain circuitsCognitively intact elderly individualsConnectivity measuresElderly individualsPatientsAlzheimer's diseaseFunctional couplingAdvanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease
Sepulcre J, Masdeu J. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods In Molecular Biology 2016, 1303: 509-519. PMID: 26235088, DOI: 10.1007/978-1-4939-2627-5_31.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional magnetic resonance imagingAlzheimer's diseaseEarly stages of Alzheimer's diseaseOxygen level-dependentMagnetic resonance imagingStages of Alzheimer's diseaseNeurobiological changesStructural neuroimagingBrain networksBrain regionsBrains of patientsPostmortem studiesLevel-dependentNeurobiology of ADFunctional networksPostmortem dataBrainQuiet wakefulnessTau depositionResonance imagingTherapeutic interventionsNetwork propertiesNeurobiologyNeuroimaging
2011
Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging.
Stufflebeam S, Liu H, Sepulcre J, Tanaka N, Buckner R, Madsen J. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. Journal Of Neurosurgery 2011, 114: 1693-7. PMID: 21351832, PMCID: PMC3248962, DOI: 10.3171/2011.1.jns10482.Peer-Reviewed Original ResearchConceptsEpileptic dischargesRefractory epilepsyMedically refractory epilepsyFocal epileptic dischargesLocalized epileptic dischargesSeizure onset zoneMagnetic resonance imagingFunctional connectivity magnetic resonance imagingStatistically significant increaseSurgical treatmentEpileptogenic areaSpontaneous brain activityInvasive electroencephalographyOnset zonePatientsResonance imagingMR imagingHigh-spatial resolutionNoninvasive methodSignificant increasePresurgical mappingFocal regionFCMREpilepsy
2009
Fractal dimension analysis of grey matter in multiple sclerosis
Esteban F, Sepulcre J, de Miras J, Navas J, de Mendizábal N, Goñi J, Quesada J, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. Journal Of The Neurological Sciences 2009, 282: 67-71. PMID: 19167728, DOI: 10.1016/j.jns.2008.12.023.Peer-Reviewed Original ResearchConceptsGray matterMagnetic resonance imagingMultiple sclerosisVoxel-based morphometry approachExtensive grey matterAttack of MST1 MRI sequencesT2 lesion loadShorter disease durationWhite matter abnormalitiesGM abnormalitiesMorphometry approachGM morphologyGM atrophyMeasures of GMLong-term disabilityDisease durationHealthy controlsHuman brainMS patientsLesion loadPatientsAbnormalitiesResonance imagingMRI sequencesFatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways
Sepulcre J, Masdeu J, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, Villoslada P. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Multiple Sclerosis Journal 2009, 15: 337-344. PMID: 18987107, DOI: 10.1177/1352458508098373.Peer-Reviewed Original ResearchConceptsMultiple sclerosisGray matter atrophyWhite matter lesion locationFatigue scoresLocation of white matter lesionsModified Fatigue Impact ScaleWhite matter lesionsMagnetic resonance imagingVoxel-based morphometry methodFatigue Impact ScaleAtrophy degreeWhite matter regionsMS-related fatigueBilateral middle frontal gyriSymptoms of fatigueLeft superior frontal gyrusLesion loadCognitive/attentional processesPatients' qualityLesion locationResonance imagingSuperior frontal gyrusImpact ScaleLesionsMiddle frontal gyri
2008
HLA‐DR2 and White Matter Lesion Distribution in MS
Sepulcre J, Masdeu J, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P. HLA‐DR2 and White Matter Lesion Distribution in MS. Journal Of Neuroimaging 2008, 18: 328-331. PMID: 18482373, DOI: 10.1111/j.1552-6569.2008.00259.x.Peer-Reviewed Original ResearchConceptsHLA-DR2Magnetic resonance imagingMultiple sclerosisLesion distributionHuman leukocyte antigen DR2White matterAntigen DR2Regional distribution of white matterGenetic risk factorsMRI patternRisk factorsResonance imagingDistribution of white matterDisease phenotypePatientsLesionsLesion phenotypeDiseasePhenotypeLesion mapsRegional distribution