2008
Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis
Pampliega O, Domercq M, Villoslada P, Sepulcre J, Rodríguez-Antigüedad A, Matute C. Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. Journal Of Neuroimmunology 2008, 195: 194-198. PMID: 18378006, DOI: 10.1016/j.jneuroim.2008.01.011.Peer-Reviewed Original ResearchConceptsMultiple sclerosisGlutamate homeostasisMS patientsPlasma glutamate levelsRelapsing multiple sclerosisGlutamate transporter EAAT2Glutamate plasma levelsGlutamate levelsRelapsing MSPlasma levelsControl subjectsTransporter expressionTransporter EAAT2Glutamate excitotoxicityGlutamate concentrationTissue damageMutant genotypesGlutamateEAAT2PatientsSclerosisPolymorphismHomeostasis
2006
Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test
Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Multiple Sclerosis Journal 2006, 12: 187-195. PMID: 16629422, DOI: 10.1191/1352458506ms1258oa.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestBRB-N testsCognitive impairmentBRB-NHealthy controlsCognitive measuresPhysical disabilityMS patientsMultiple sclerosisModal testingImpairmentBriefIndividual testsCut-off valueDisabilityEducation levelRelapsing MSZ-scoreProgressive MSPatientsMonitoring patientsIllnessLevel of controlSclerosisStandard deviation