2021
Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Amariglio R, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.053011.Peer-Reviewed Original ResearchCognitively-normal individualsCortical mean diffusivityCognitive declineMiddle-temporal gyrusHarvard Aging Brain StudyInferior temporal tauPreclinical Alzheimer Cognitive CompositeAging Brain StudyHealthy older adultsRegional cortical thicknessAmyloid-bShort-term cognitive declineDiffusion-weighted imagingBrain gray matterClinical progressionNeuronal injuryC-PiB PETCognitive compositeProgression to MCIGray-matterRegions-of-interestCognitive AssessmentFTP-PETPACC5Cortical thickness
2020
The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Fortea J, Johnson K, Sperling R, Vannini P. The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.041626.Peer-Reviewed Original ResearchCortical mean diffusivityC-PiB PETTemporo-parietal brain regionsHarvard Aging Brain StudyAmyloid-bAlzheimer's diseaseMean diffusivityPreclinical stage of Alzheimer's diseaseAging Brain StudyGray matterPreclinical Alzheimer's diseaseStages of Alzheimer's diseaseCerebellar gray matterBrain regionsRegions-of-interestTemporal regionsSurface-based approachEntorhinal cortexBrain studiesGlial activationBrain microstructural propertiesLongitudinal studyCortical MDNon-linear trajectoriesCortical microstructure