Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway
Sepulcre J, Goñi J, Masdeu J, Bejarano B, de Mendizábal N, Toledo J, Villoslada P. Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway. JAMA Neurology 2009, 66: 173-179. PMID: 19204153, DOI: 10.1001/archneurol.2008.562.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleus atrophyGM atrophyMultiple sclerosisOptic pathway lesionsOptical radiationWhite matterOptic radiation lesionsGray matterWM regionsRegional GM atrophyWhite matter lesionsLesion probability mapsVoxel-based analysisT1 lesionsPathway lesionsLateral geniculate nucleusRadiation lesionsPresence of lesionsMultiple Sclerosis CenterGray matter atrophyOptic pathwayMultiple sclerosis plaquesAtrophyLesionsAxonal injury