2022
Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease
Basaia S, Agosta F, Diez I, Bueichekú E, Uquillas F, Delgado-Alvarado M, Caballero-Gaudes C, Rodriguez-Oroz M, Stojkovic T, Kostic V, Filippi M, Sepulcre J. Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease. NeuroImage Clinical 2022, 33: 102941. PMID: 35091253, PMCID: PMC8800137, DOI: 10.1016/j.nicl.2022.102941.Peer-Reviewed Original ResearchConceptsParkinson's diseaseBrain circuitsGene expression patternsBrain connectivityPD-related pathologyPD participantsHuman brainHuman cortexTopological intersectionConnectivity networksCortical propagation patternsPostmortem dataGenetic traitsBrainExpression patternsSNCA geneConnectivity trajectoriesGenesCellular componentsNeuronal damageNeuronal vulnerabilityVulnerabilityParkinsonTraits
2018
PET staging of amyloidosis using striatum
Hanseeuw B, Betensky R, Mormino E, Schultz A, Sepulcre J, Becker J, Jacobs H, Buckley R, LaPoint M, Vannini P, Donovan N, Chhatwal J, Marshall G, Papp K, Amariglio R, Rentz D, Sperling R, Johnson K, Initiative F, Study A. PET staging of amyloidosis using striatum. Alzheimer's & Dementia 2018, 14: 1281-1292. PMID: 29792874, PMCID: PMC6219621, DOI: 10.1016/j.jalz.2018.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmyloid beta-PeptidesAmyloidosisApolipoprotein E4Brain ConcussionCognitive DysfunctionCorpus StriatumDisease ProgressionFemaleFollow-Up StudiesHumansImage Interpretation, Computer-AssistedLongitudinal StudiesMalePositron-Emission TomographyProspective StudiesSeverity of Illness IndexConceptsPositron emission tomographyHippocampal volumeCortical amyloidInvolvement of cortexPositron emission tomography dataStriatal signalingPositron emission tomography classificationAmyloid positron emission tomographyStriatumCognitive declineCortical measuresCortexPostmortem dataCognitionCortical depositsEmission tomographyIncreased predictive powerDementia progressionAdvanced amyloidosisDementia researchAlzheimerPET dataStriatalFollow-up dataPredictive power
2016
Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease
Sepulcre J, Masdeu J. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods In Molecular Biology 2016, 1303: 509-519. PMID: 26235088, DOI: 10.1007/978-1-4939-2627-5_31.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional magnetic resonance imagingAlzheimer's diseaseEarly stages of Alzheimer's diseaseOxygen level-dependentMagnetic resonance imagingStages of Alzheimer's diseaseNeurobiological changesStructural neuroimagingBrain networksBrain regionsBrains of patientsPostmortem studiesLevel-dependentNeurobiology of ADFunctional networksPostmortem dataBrainQuiet wakefulnessTau depositionResonance imagingTherapeutic interventionsNetwork propertiesNeurobiologyNeuroimaging