Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders
Perez D, Matin N, Barsky A, Costumero-Ramos V, Makaretz S, Young S, Sepulcre J, LaFrance W, Keshavan M, Dickerson B. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. Journal Of Neurology Neurosurgery & Psychiatry 2017, 88: 491. PMID: 28416565, PMCID: PMC5497745, DOI: 10.1136/jnnp-2016-314998.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexChildChild AbuseConversion DisorderDominance, CerebralFemaleGray MatterGyrus CinguliHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalLife Change EventsMagnetic Resonance ImagingMaleMiddle AgedNervous System DiseasesOrgan SizePsychophysiologic DisordersStatistics as TopicStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional neurological symptomsFunctional neurological disorderAnterior cingulate cortexSelf-report measuresInsular volumeChildhood abuseVolumetric associationsSymptom severityPost-traumatic stress disorder symptom severityAssociated with left hippocampal volumeAdverse early-life eventsFunctional neurological disorder patientsLeft hippocampal volumeAdverse life eventsPatient Health Questionnaire-15Neurological symptom severityEarly-life eventsACC volumeDisorder subscaleGender-specific effectsCingulate cortexStress disorderHippocampal volume