Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Sepulcre J, Grothe M, Sabuncu M, Chhatwal J, Schultz A, Hanseeuw B, Fakhri G, Sperling R, Johnson K. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology 2017, 74: 813-820. PMID: 28558094, PMCID: PMC5710537, DOI: 10.1001/jamaneurol.2017.0263.Peer-Reviewed Original ResearchConceptsHeteromodal areasTemporal lobeHarvard Aging Brain StudyHeteromodal association regionsAging Brain StudyCognitively normal participantsElderly brainsPositron emission tomographicPrimary somatomotor cortexDistribution volume ratioAlzheimer's diseaseTau depositionStandardized uptake value ratioVisual regionsNormal participantsAb depositionSomatomotor cortexTemporal areaPittsburgh compound BCarbon 11-labeled Pittsburgh Compound BBrain studiesAssociation regionsHuman brainPathological hallmarks of Alzheimer's diseaseCortical distributionAssociation of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease
Xia C, Makaretz S, Caso C, McGinnis S, Gomperts S, Sepulcre J, Gomez-Isla T, Hyman B, Schultz A, Vasdev N, Johnson K, Dickerson B. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurology 2017, 74: 427-436. PMID: 28241163, PMCID: PMC5470368, DOI: 10.1001/jamaneurol.2016.5755.Peer-Reviewed Original ResearchConceptsStructural magnetic resonance imagingAlzheimer's diseaseCortical atrophyHyperphosphorylated tau proteinClinical phenotypeTau in vivoAssociation in vivoAtypical Alzheimer's diseaseMagnetic resonance imagingTau proteinMeasure amyloid burdenPositron emission tomographicNeurofibrillary tanglesMeasure cortical thicknessOutpatient referral centerDisease-modifying therapeuticsTau PET imagingCarbon 11-labeled Pittsburgh Compound BCognitive functionIn vivo evidenceCortical regionsResonance imagingPostmortem studiesCortical thicknessNeurodegenerative diseases