2023
Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor
Lin J, Kang X, Lu H, Zhang D, Bian X, Zhou J, Hu J, Zhang D, Sepulcre J, Pan L, Lou X. Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor. Neurotherapeutics 2023, 20: 1755-1766. PMID: 37843768, PMCID: PMC10684443, DOI: 10.1007/s13311-023-01442-9.Peer-Reviewed Original ResearchConceptsMRgFUS thalamotomyET patientsEssential tremorMagnetic resonance-guided focused ultrasoundMatched health controlsPostoperative 6 monthsTremor symptomsHealth controlsFunctional MR imagingMRgFUSPatientsFeatures of Parkinson's diseaseThalamotomyRobust alterationsMR imagingPosterior cingulate cortexFocused ultrasoundCingulate cortexSymptomsNeurological diseasesAlterationsParkinson's diseaseSymptom predictionDiseaseTremor
2020
Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia
DuBois J, Mathotaarachchi S, Rousset O, Sziklas V, Sepulcre J, Guiot M, Hall J, Massarweh G, Soucy J, Rosa-Neto P, Kobayashi E. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. NeuroImage Clinical 2020, 29: 102552. PMID: 33401137, PMCID: PMC7787952, DOI: 10.1016/j.nicl.2020.102552.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasia patientsFocal cortical dysplasiaHealthy controlsCortical dysplasiaFCD patientsMetabotropic glutamate receptor type 5Contralateral hemisphereEpileptic activityPersistent epileptic activityDuration of epilepsySmall-world connectivityHigh centrality nodesMGluR5 availabilityIn vivo evidenceEpilepsy durationPatientsType 5Assess group differencesNetwork integrationMGluR5Binding potentialDysplasiaNetwork abnormalitiesGraph theoretical analysisEpilepsy
2016
Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications
Teipel S, Grothe M, Zhou J, Sepulcre J, Dyrba M, Sorg C, Babiloni C. Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications. Journal Of The International Neuropsychological Society 2016, 22: 138-163. PMID: 26888613, DOI: 10.1017/s1355617715000995.Peer-Reviewed Original ResearchConceptsCortical connectivityMild cognitive impairmentClinical applicationFunctional cortical connectivityMagnetic resonance imagingWhite matter bundlesResting-state functional magnetic resonance imagingDiffusion tensor imagingBlood oxygen level-dependent activityPre-clinicalEEG rhythmsCerebral reserve capacityResonance imagingNetwork pathologyAttention-related networksIn vivoMild AD dementia patientsTensor imagingBrain circuitsCognitively intact elderly individualsConnectivity measuresElderly individualsPatientsAlzheimer's diseaseFunctional coupling
2011
Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging.
Stufflebeam S, Liu H, Sepulcre J, Tanaka N, Buckner R, Madsen J. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. Journal Of Neurosurgery 2011, 114: 1693-7. PMID: 21351832, PMCID: PMC3248962, DOI: 10.3171/2011.1.jns10482.Peer-Reviewed Original ResearchConceptsEpileptic dischargesRefractory epilepsyMedically refractory epilepsyFocal epileptic dischargesLocalized epileptic dischargesSeizure onset zoneMagnetic resonance imagingFunctional connectivity magnetic resonance imagingStatistically significant increaseSurgical treatmentEpileptogenic areaSpontaneous brain activityInvasive electroencephalographyOnset zonePatientsResonance imagingMR imagingHigh-spatial resolutionNoninvasive methodSignificant increasePresurgical mappingFocal regionFCMREpilepsy
2009
Fractal dimension analysis of grey matter in multiple sclerosis
Esteban F, Sepulcre J, de Miras J, Navas J, de Mendizábal N, Goñi J, Quesada J, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. Journal Of The Neurological Sciences 2009, 282: 67-71. PMID: 19167728, DOI: 10.1016/j.jns.2008.12.023.Peer-Reviewed Original ResearchConceptsGray matterMagnetic resonance imagingMultiple sclerosisVoxel-based morphometry approachExtensive grey matterAttack of MST1 MRI sequencesT2 lesion loadShorter disease durationWhite matter abnormalitiesGM abnormalitiesMorphometry approachGM morphologyGM atrophyMeasures of GMLong-term disabilityDisease durationHealthy controlsHuman brainMS patientsLesion loadPatientsAbnormalitiesResonance imagingMRI sequences
2008
Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis
Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Multiple Sclerosis Journal 2008, 14: 906-912. PMID: 18573835, DOI: 10.1177/1352458508090221.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerHeidelberg retinal tomographyOptical coherence tomographyMultiple sclerosisRetinal nerve fiber layer thickness measurementsRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessCompare optical coherence tomographyNerve fiber layer atrophyNerve fiber layerAssociated with physical disabilityRetinal tomographyFiber layerCoherence tomographyAxonal lossNeurological examinationMatched controlsSymbol Digit Modalities TestTissue changesPatientsCognitive disabilitiesAtrophyMS evolutionDetect thinningTomographyHLA‐DR2 and White Matter Lesion Distribution in MS
Sepulcre J, Masdeu J, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P. HLA‐DR2 and White Matter Lesion Distribution in MS. Journal Of Neuroimaging 2008, 18: 328-331. PMID: 18482373, DOI: 10.1111/j.1552-6569.2008.00259.x.Peer-Reviewed Original ResearchConceptsHLA-DR2Magnetic resonance imagingMultiple sclerosisLesion distributionHuman leukocyte antigen DR2White matterAntigen DR2Regional distribution of white matterGenetic risk factorsMRI patternRisk factorsResonance imagingDistribution of white matterDisease phenotypePatientsLesionsLesion phenotypeDiseasePhenotypeLesion mapsRegional distributionAssociation of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis
Pampliega O, Domercq M, Villoslada P, Sepulcre J, Rodríguez-Antigüedad A, Matute C. Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. Journal Of Neuroimmunology 2008, 195: 194-198. PMID: 18378006, DOI: 10.1016/j.jneuroim.2008.01.011.Peer-Reviewed Original ResearchConceptsMultiple sclerosisGlutamate homeostasisMS patientsPlasma glutamate levelsRelapsing multiple sclerosisGlutamate transporter EAAT2Glutamate plasma levelsGlutamate levelsRelapsing MSPlasma levelsControl subjectsTransporter expressionTransporter EAAT2Glutamate excitotoxicityGlutamate concentrationTissue damageMutant genotypesGlutamateEAAT2PatientsSclerosisPolymorphismHomeostasisIL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis
Martinez‐Forero I, Garcia‐Munoz R, Martinez‐Pasamar S, Inoges S, de Cerio A, Palacios R, Sepulcre J, Moreno B, Gonzalez Z, Fernandez‐Diez B, Melero I, Bendandi M, Villoslada P. IL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. European Journal Of Immunology 2008, 38: 576-586. PMID: 18200504, DOI: 10.1002/eji.200737271.Peer-Reviewed Original ResearchConceptsTr1 cellsCD4(+) cellsIL-10R signalingIL-10MS patientsIL-10 stimulationIL-10RMultiple sclerosisIL-10R signaling pathwayIL-10RA geneCell type 1Anti-CD46 antibodiesExpression of cytokinesSTAT-3 phosphorylationInduced in vitroReal-time PCRCell therapyIL-10RASuppression assaysPatientsSuppressor activityType 1Baseline levelsCell functionSTAT-3
2007
Fractal dimension and white matter changes in multiple sclerosis
Esteban F, Sepulcre J, de Mendizábal N, Goñi J, Navas J, de Miras J, Bejarano B, Masdeu J, Villoslada P. Fractal dimension and white matter changes in multiple sclerosis. NeuroImage 2007, 36: 543-549. PMID: 17499522, DOI: 10.1016/j.neuroimage.2007.03.057.Peer-Reviewed Original ResearchConceptsMultiple sclerosisHealthy controlsCentrum semiovale levelWhite matterConventional MR imagingGray-white matter interfaceMR imaging sectionsVoxel-based morphometry approachCentral nervous systemConventional magnetic resonanceWhite matter changesWM abnormalitiesPatientsMR imagingMS lesionsNervous systemBrain white matterMatter changesMagnetic resonanceNAWMBrain WMBrains of patientsLesionsBrainEarly phase
2006
Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test
Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Multiple Sclerosis Journal 2006, 12: 187-195. PMID: 16629422, DOI: 10.1191/1352458506ms1258oa.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestBRB-N testsCognitive impairmentBRB-NHealthy controlsCognitive measuresPhysical disabilityMS patientsMultiple sclerosisModal testingImpairmentBriefIndividual testsCut-off valueDisabilityEducation levelRelapsing MSZ-scoreProgressive MSPatientsMonitoring patientsIllnessLevel of controlSclerosisStandard deviation