2022
The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults
Gagliardi G, Rodriguez‐Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz A, Properzi M, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065744.Peer-Reviewed Original ResearchCortical mean diffusivityCognitive declineOlder adultsCognitively-normal older adultsHarvard Aging Brain StudyAD-related cognitive declinePreclinical Alzheimer Cognitive CompositeCognitively-normal adultsAging Brain StudyAccumulation of tau pathologyAPOE e4 statusBrain microstructural changesCognitive compositeTau accumulationPACC5Gray-matterCognitive AssessmentCognitive impairmentFTP-PETAt-risk individualsAPOE-e4 carriersBrain studiesApo E4E4 statusMean diffusivity
2021
Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Amariglio R, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.053011.Peer-Reviewed Original ResearchCognitively-normal individualsCortical mean diffusivityCognitive declineMiddle-temporal gyrusHarvard Aging Brain StudyInferior temporal tauPreclinical Alzheimer Cognitive CompositeAging Brain StudyHealthy older adultsRegional cortical thicknessAmyloid-bShort-term cognitive declineDiffusion-weighted imagingBrain gray matterClinical progressionNeuronal injuryC-PiB PETCognitive compositeProgression to MCIGray-matterRegions-of-interestCognitive AssessmentFTP-PETPACC5Cortical thickness