Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease
Basaia S, Agosta F, Diez I, Bueichekú E, Uquillas F, Delgado-Alvarado M, Caballero-Gaudes C, Rodriguez-Oroz M, Stojkovic T, Kostic V, Filippi M, Sepulcre J. Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease. NeuroImage Clinical 2022, 33: 102941. PMID: 35091253, PMCID: PMC8800137, DOI: 10.1016/j.nicl.2022.102941.Peer-Reviewed Original ResearchConceptsParkinson's diseaseBrain circuitsGene expression patternsBrain connectivityPD-related pathologyPD participantsHuman brainHuman cortexTopological intersectionConnectivity networksCortical propagation patternsPostmortem dataGenetic traitsBrainExpression patternsSNCA geneConnectivity trajectoriesGenesCellular componentsNeuronal damageNeuronal vulnerabilityVulnerabilityParkinsonTraits