2017
Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease
Xia C, Makaretz S, Caso C, McGinnis S, Gomperts S, Sepulcre J, Gomez-Isla T, Hyman B, Schultz A, Vasdev N, Johnson K, Dickerson B. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurology 2017, 74: 427-436. PMID: 28241163, PMCID: PMC5470368, DOI: 10.1001/jamaneurol.2016.5755.Peer-Reviewed Original ResearchConceptsStructural magnetic resonance imagingAlzheimer's diseaseCortical atrophyHyperphosphorylated tau proteinClinical phenotypeTau in vivoAssociation in vivoAtypical Alzheimer's diseaseMagnetic resonance imagingTau proteinMeasure amyloid burdenPositron emission tomographicNeurofibrillary tanglesMeasure cortical thicknessOutpatient referral centerDisease-modifying therapeuticsTau PET imagingCarbon 11-labeled Pittsburgh Compound BCognitive functionIn vivo evidenceCortical regionsResonance imagingPostmortem studiesCortical thicknessNeurodegenerative diseases
2015
A Spectral Graph Regression Model for Learning Brain Connectivity of Alzheimer’s Disease
Hu C, Cheng L, Sepulcre J, Johnson K, Fakhri G, Lu Y, Li Q. A Spectral Graph Regression Model for Learning Brain Connectivity of Alzheimer’s Disease. PLOS ONE 2015, 10: e0128136. PMID: 26024224, PMCID: PMC4449104, DOI: 10.1371/journal.pone.0128136.Peer-Reviewed Original ResearchConceptsNetwork featuresAlzheimer's diseaseConsistent with known pathologyUnknown graphConnection weightsReconstruction networkCortical hubsDegree statisticsData modelSmooth signalsFeatures of brain pathologyOptimization frameworkAmyloid-bPartial correlation estimationImage dataNetworkGraphGlobal connectivity measuresPositron emission tomographyConnectivity measuresNeurodegenerative diseasesConnectivity patternsSample correlationClinical ADSimulated data
2013
In vivo characterization of the early states of the amyloid-beta network
Sepulcre J, Sabuncu M, Becker A, Sperling R, Johnson K. In vivo characterization of the early states of the amyloid-beta network. Brain 2013, 136: 2239-2252. PMID: 23801740, PMCID: PMC3692037, DOI: 10.1093/brain/awt146.Peer-Reviewed Original ResearchConceptsAmyloid-bAlzheimer's diseasePittsburgh compound B positron emission tomography imagingPrecuneus/posterior cingulate cortexMedial temporal lobeRegional brain atrophyAlzheimer's disease pathologyAmyloid-betaOrbitofrontal cortexCingulate cortexAmygdala nucleiTemporal lobeCortical regionsAssociated with accumulationHub propertiesEmission tomography imagingNeurodegenerative diseasesBrain atrophyDisease pathologyAlzheimerHippocampusAbnormal accumulationCortexIn vivo characterizationElderly subjectsA GRAPH THEORETICAL REGRESSION MODEL FOR BRAIN CONNECTIVITY LEARNING OF ALZHEIMER'S DISEASE
Hu C, Cheng L, Sepulcre J, Fakhri G, Lu Y, Li Q. A GRAPH THEORETICAL REGRESSION MODEL FOR BRAIN CONNECTIVITY LEARNING OF ALZHEIMER'S DISEASE. 2013, 616-619. DOI: 10.1109/isbi.2013.6556550.Peer-Reviewed Original Research
2008
A computational analysis of protein-protein interaction networks in neurodegenerative diseases
Goñi J, Esteban F, de Mendizábal N, Sepulcre J, Ardanza-Trevijano S, Agirrezabal I, Villoslada P. A computational analysis of protein-protein interaction networks in neurodegenerative diseases. BMC Systems Biology 2008, 2: 52. PMID: 18570646, PMCID: PMC2443111, DOI: 10.1186/1752-0509-2-52.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsAnalysis of protein-protein interaction networksProtein-protein interaction informationProtein-protein interaction networkAlzheimer's diseaseNeurodegenerative diseasesProtein-protein interaction analysisSeed proteinStudy of biological networksGene expression studiesDNA array experimentsProperties of proteinsMultifactorial neurodegenerative diseaseAD brainInteraction networkExpression studiesBiological networksGene expressionBackgroundRecent developmentsMolecular pathwaysGenesArray experimentsComputational analysisParameters of degreePathway