2009
Brain pathways of verbal working memory A lesion–function correlation study
Sepulcre J, Masdeu J, Pastor M, Goñi J, Barbosa C, Bejarano B, Villoslada P. Brain pathways of verbal working memory A lesion–function correlation study. NeuroImage 2009, 47: 773-778. PMID: 19393745, DOI: 10.1016/j.neuroimage.2009.04.054.Peer-Reviewed Original ResearchConceptsVerbal working memoryWorking memoryWhite matter pathwaysWhite matter regionsMatter regionsVerbal working memory taskDisrupted white matter pathwaysRight cerebellar white matterWorking memory taskWhite matter connectivityMemory taskGray matter regionsCognitive processesCognitive functionThalamo-cortical projectionsInformation processingHuman brainMagnetic resonance imagingMemoryCerebellar white matterWhite matterWhite matter lesionsLeft-sided predominanceBrainMultiple sclerosis patients
2008
Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain
Sepulcre J, Masdeu J, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor M, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. NeuroImage 2008, 42: 1237-1243. PMID: 18585467, DOI: 10.1016/j.neuroimage.2008.05.038.Peer-Reviewed Original ResearchConceptsAnterior temporal stemDeclarative verbal memoryLiving human brainVerbal memoryTemporal stemDisrupted white matter pathwaysVerbal memory processesHuman brainFronto-occipital fasciculusWhite matter pathwaysMemory processesLeft hemisphereBrain pathwaysWhite matter regionsWhite matter lesionsAnterior limbThalamic regionsMemory storageMatter regionsMagnetic resonance imagingBrainInternal capsuleWhite matterMemoryMultiple sclerosis patients
2006
Methylthioadenosine reverses brain autoimmune disease
Moreno B, Hevia H, Santamaria M, Sepulcre J, Muñoz J, García‐Trevijano E, Berasain C, Corrales F, Avila M, Villoslada P. Methylthioadenosine reverses brain autoimmune disease. Annals Of Neurology 2006, 60: 323-334. PMID: 16786535, DOI: 10.1002/ana.20895.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAmyloid beta-Protein PrecursorAnimalsCytokinesDisease Models, AnimalDose-Response Relationship, DrugDrug InteractionsEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmunologic FactorsLymphocytesMacrophagesMaleMiddle AgedMultiple SclerosisNitric Oxide Synthase Type IIPhytohemagglutininsRatsRats, Inbred LewReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStatistics, NonparametricThionucleosidesConceptsExperimental autoimmune encephalomyelitisAutoimmune diseasesChronic relapsing EAET cell activation in vivoAcute experimental autoimmune encephalomyelitisExperimental autoimmune encephalomyelitis animalsPeripheral blood mononuclear cellsMultiple sclerosisChronic EAE modelHealthy control subjectsInhibiting brain inflammationBlood mononuclear cellsProduction of antiinflammatory cytokinesRodent experimental autoimmune encephalomyelitisImmunomodulatory activityPrevention of inhibitorsTranscription factor nuclear factor-kappaB.Cytokine gene expressionNuclear factor-kappaB.Real-time polymerase chain reactionReduced brain damageT cell signalingMultiple sclerosis patientsAutoimmune encephalomyelitisEAE model