2020
Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade
Labayru G, Jimenez‐Marin A, Fernández E, Villanua J, Zulaica M, Cortes J, Díez I, Sepulcre J, de Munain A, Sistiaga A. Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade. Annals Of Clinical And Translational Neurology 2020, 7: 1802-1815. PMID: 32881379, PMCID: PMC7545612, DOI: 10.1002/acn3.51163.Peer-Reviewed Original ResearchConceptsVoxel Based MorphometryHealthy controlsFronto-subcortical networksPatterns of brain atrophyMultimodal integration networkExecutive function testsBrain structural abnormalitiesRegional brain volumesGM damageDM1 patientsNeuropsychological testsNeurodevelopmental originBrain changesPediatric onset patientsGM lossFrontal regionsVBM analysisWM volumeBrain abnormalitiesBrain volumeCognitive outcomesFollow-up MRI studiesHC groupYoung adulthoodImpairment assessment
2019
Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder
Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina J, Dickerson B, Keshavan M, LaFrance W, Sepulcre J, Perez D. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. Journal Of Neurology Neurosurgery & Psychiatry 2019, 90: 929. PMID: 30850473, PMCID: PMC6625895, DOI: 10.1136/jnnp-2018-319657.Peer-Reviewed Original ResearchConceptsFunctional neurological disorderLeft anterior insulaRight anterior insulaAnterior insulaSymptom severityWithin-group analysisPathophysiology of functional neurological disorderFunctional neurological disorder cohortsMotor functional neurological disorderRight laterobasal amygdalaMultimodal integration networkBilateral posterior insulaMiddle cingulate cortexMultimodal integration areasLaterobasal amygdalaDisorder subscaleCentromedial amygdalaCingulate cortexInteroceptive processingAffective disturbancesPatient-reported symptom severityPosterior insulaWithin-group associationsAmygdalar nucleiBetween-group differences
2014
Integration of visual and motor functional streams in the human brain
Sepulcre J. Integration of visual and motor functional streams in the human brain. Neuroscience Letters 2014, 567: 68-73. PMID: 24699175, DOI: 10.1016/j.neulet.2014.03.050.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional connectivity structureMultimodal integration networkHuman functional connectomeHuman brainBrain imaging methodsSynchronous brain activityOxygen level-dependentBrain regionsBrain activityFunctional streamsFunctional connectomeCerebral areasLevel-dependentInformation processingBrain researchBrainConnection structureCoupling patternsCoupling
2012
Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain
Sepulcre J, Sabuncu M, Yeo T, Liu H, Johnson K. Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain. Journal Of Neuroscience 2012, 32: 10649-10661. PMID: 22855814, PMCID: PMC3483645, DOI: 10.1523/jneurosci.0759-12.2012.Peer-Reviewed Original ResearchConceptsHigher-order brain systemsMultimodal integration networkOrganization of brain regionsHuman brainCognitive processing systemsPosterior parietal cortexBrain systemsNeuroimaging researchParietal cortexBrain regionsInternal cognitionPerceptual integrationFunctional connectomeModality-relatedMultimodal organizationPerceptual convergenceMultimodal integrationCortexBrainMultimode processesCognitionCoherence experimentsConnectomeConnective axisProcessing system