2021
Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children
Suñol M, Alemany S, Bustamante M, Diez I, Contreras-Rodríguez O, Laudo B, Macià D, Martínez-Vilavella G, Martínez-Zalacaín I, Menchón J, Pujol J, Sunyer J, Sepulcre J, Soriano-Mas C. Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children. Biological Psychiatry Global Open Science 2021, 2: 411-420. PMID: 36324658, PMCID: PMC9616269, DOI: 10.1016/j.bpsgos.2021.11.009.Peer-Reviewed Original ResearchObsessive-compulsive symptomsDynamic functional connectivityObsessive-compulsive disorderBrain circuitsGlutamatergic neurotransmissionBrain regionsNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderObsessive Compulsive Inventory-Child VersionResting-state functional magnetic resonance imaging examinationObsessive–compulsive disorder samplesPatterns of dynamic functional connectivityRight superior parietal cortexAssociated with connectivity changesDynamic functional connectivity changesInvolvement of glutamatergic neurotransmissionLeft ventral putamenFunctional magnetic resonance imaging examinationSuperior parietal cortexStable connectivity patternsBrain network changesGraph theory-based approachNeurobiological modelsVentral putamenSymptom levels
2014
Default mode network subsystem alterations in obsessive–compulsive disorder
Beucke J, Sepulcre J, Eldaief M, Sebold M, Kathmann N, Kaufmann C. Default mode network subsystem alterations in obsessive–compulsive disorder. The British Journal Of Psychiatry 2014, 205: 376-382. PMID: 25257066, DOI: 10.1192/bjp.bp.113.137380.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderAssociated with self-referential processingModels of obsessive-compulsive disorderSeed-based resting-state functional connectivityObsessive-compulsive disorder groupHistory of affective disorderResting-state functional connectivityFunctional magnetic resonance imagingSelf-referential processingCorticostriatal brain regionsLife-time historyMode network componentsNeurobiological modelsAffective disordersBrain regionsFunctional connectivityReduced connectivityNeural systemsMedical statusAttention networkDisordered backgroundMagnetic resonance imagingDisordersNetwork integration
2013
Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Beucke J, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder. JAMA Psychiatry 2013, 70: 619-629. PMID: 23740050, DOI: 10.1001/jamapsychiatry.2013.173.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderOrbitofrontal cortexUnmedicated patientsAntidepressant medicationBasal gangliaSymptom severityObsessive-compulsive disorder symptom severityConsistent with neurobiological modelsTreated with antidepressant medicationResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingOCD symptom severityReduced local connectivityLocal functional connectivityBrain network propertiesDegree connectivityStatistical parametric mappingVentral striatumCase-control cross-sectional studyCorticostriatal circuitryNeurobiological modelsBrain circuitsConnectivity alterations