2022
The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults
Gagliardi G, Rodriguez‐Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz A, Properzi M, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065744.Peer-Reviewed Original ResearchCortical mean diffusivityCognitive declineOlder adultsCognitively-normal older adultsHarvard Aging Brain StudyAD-related cognitive declinePreclinical Alzheimer Cognitive CompositeCognitively-normal adultsAging Brain StudyAccumulation of tau pathologyAPOE e4 statusBrain microstructural changesCognitive compositeTau accumulationPACC5Gray-matterCognitive AssessmentCognitive impairmentFTP-PETAt-risk individualsAPOE-e4 carriersBrain studiesApo E4E4 statusMean diffusivity
2020
The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Fortea J, Johnson K, Sperling R, Vannini P. The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.041626.Peer-Reviewed Original ResearchCortical mean diffusivityC-PiB PETTemporo-parietal brain regionsHarvard Aging Brain StudyAmyloid-bAlzheimer's diseaseMean diffusivityPreclinical stage of Alzheimer's diseaseAging Brain StudyGray matterPreclinical Alzheimer's diseaseStages of Alzheimer's diseaseCerebellar gray matterBrain regionsRegions-of-interestTemporal regionsSurface-based approachEntorhinal cortexBrain studiesGlial activationBrain microstructural propertiesLongitudinal studyCortical MDNon-linear trajectoriesCortical microstructure
2018
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs H, Hedden T, Schultz A, Sepulcre J, Perea R, Amariglio R, Papp K, Rentz D, Sperling R, Johnson K. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience 2018, 21: 424-431. PMID: 29403032, PMCID: PMC5857215, DOI: 10.1038/s41593-018-0070-z.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory declineCingulate cortexHippocampal volumeTau accumulationAssociated with increased mean diffusivityCognitively healthy older individualsBaseline hippocampal volumeAmyloid-positive individualsWhite matter connectivityAmyloid-negative individualsPreclinical Alzheimer's diseaseAmyloid pathologyAnimal models of Alzheimer's diseaseHealthy older individualsTau pathology propagationModel of Alzheimer's diseaseAlzheimer's diseaseTau positron emission tomographyMemory performanceNeural vulnerabilityCingulum bundleOlder individualsPositron emission tomographyMean diffusivity