2017
The association between tau PET and retrospective cortical thinning in clinically normal elderly
LaPoint M, Chhatwal J, Sepulcre J, Johnson K, Sperling R, Schultz A. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage 2017, 157: 612-622. PMID: 28545932, PMCID: PMC5772972, DOI: 10.1016/j.neuroimage.2017.05.049.Peer-Reviewed Original ResearchConceptsTemporal regionsCortical thinningCortical ROIsCortical thicknessRetrospective longitudinal analysisRight temporal regionAssociated with neuronal lossBaseline ageNormal cohortNeuronal lossRate of cortical thinningLeft cuneusPathologyMedial temporal regionsVolumetric ROIsReference regionAtrophyThick cross-sectionsCortical regionsBilateral parahippocampal cortexLongitudinal atrophyLongitudinal analysisLeft superior temporal sulcusCortexBrain studies
2011
The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease
Sabuncu M, Desikan R, Sepulcre J, Yeo B, Liu H, Schmansky N, Reuter M, Weiner M, Buckner R, Sperling R, Fischl B, Initiative F. The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease. JAMA Neurology 2011, 68: 1040-1048. PMID: 21825241, PMCID: PMC3248949, DOI: 10.1001/archneurol.2011.167.Peer-Reviewed Original ResearchConceptsMini-Mental State Examination scoreHippocampal volume lossMini-MentalDecreased cognitive performanceCognitive performanceExamination scoresCortical thinningCortical regionsMeasures of cognitive performanceMulticenter case-control studyBaseline hippocampal volumeRate of hippocampal volume lossStudies of neuroimagingMild cognitive impairmentCross-subject analysisAnnual rate of hippocampal volume lossAlzheimer's Disease Neuroimaging InitiativeStudy participantsDementia stagesVolume lossHippocampal volumeIndicators of ADCognitive impairmentHippocampal atrophyLongitudinal atrophy