2022
Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
Marcos-Vidal L, Martínez-García M, Blas D, Navas-Sánchez F, Pretus C, Ramos-Quiroga J, Richarte V, Vilarroya Ó, Sepulcre J, Desco M, Carmona S. Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults. Journal Of Attention Disorders 2022, 26: 1563-1575. PMID: 35947490, DOI: 10.1177/10870547211031998.Peer-Reviewed Original ResearchConceptsIncreased local connectivityFunctional connectivityAtypical functional connectivity patternsAssociations with symptom severity scoresDistant functional connectivityDistribution of functional connectivityLocal functional connectivityFunctional connectivity patternsDecreased local connectivityADHD sampleNeuroimaging studiesAdult samplesDeficient integrationADHDSymptom severity scoresChild sampleInterference hypothesisLocal connectivityDelay hypothesisDMNConnectivity patternsHealthy controlsDistant connectionsAdultsDistant distributionLocal Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
Marcos-Vidal L, Martínez-García M, de Blas D, Navas-Sánchez F, Pretus C, Ramos-Quiroga J, Richarte V, Vilarroya Ó, Sepulcre J, Desco M, Carmona S. Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults. Journal Of Attention Disorders 2022, 26: 1788-1801. PMID: 35684934, DOI: 10.1177/10870547221101646.Peer-Reviewed Original ResearchConceptsIncreased local connectivityFunctional connectivityAtypical functional connectivity patternsAssociations with symptom severity scoresDistant functional connectivityDistribution of functional connectivityLocal functional connectivityFunctional connectivity patternsDecreased local connectivityADHD sampleNeuroimaging studiesAdult samplesDeficient integrationADHDSymptom severity scoresChild sampleInterference hypothesisLocal connectivityDelay hypothesisDMNConnectivity patternsHealthy controlsDistant connectionsAdultsDistant distribution
2018
Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder
Marcos‐Vidal L, Martínez‐García M, Pretus C, Garcia‐Garcia D, Martínez K, Janssen J, Vilarroya O, Castellanos F, Desco M, Sepulcre J, Carmona S. Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder. Human Brain Mapping 2018, 39: 2442-2454. PMID: 29473262, PMCID: PMC6866394, DOI: 10.1002/hbm.24013.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderND childrenFunctional connectivityAttention-deficit/hyperactivityFronto-parietalGroup differencesSomatomotor areasAttention-deficit/hyperactivity disorder symptomsSeverity of ADHD symptomsAttention-deficit/hyperactivity disorder diagnosisAtypical functional connectivityMaturational lag hypothesisVentral attention networkAtypical developmental patternPotential group differencesIncreased local connectivityFunctional networksHuman brain changesMultiple brain regionsLocal functional connectivityImmature functional stateBrain functional networksSeverity of clinical symptomsADHD symptomsSomatomotor regions
2013
Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Beucke J, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder. JAMA Psychiatry 2013, 70: 619-629. PMID: 23740050, DOI: 10.1001/jamapsychiatry.2013.173.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderOrbitofrontal cortexUnmedicated patientsAntidepressant medicationBasal gangliaSymptom severityObsessive-compulsive disorder symptom severityConsistent with neurobiological modelsTreated with antidepressant medicationResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingOCD symptom severityReduced local connectivityLocal functional connectivityBrain network propertiesDegree connectivityStatistical parametric mappingVentral striatumCase-control cross-sectional studyCorticostriatal circuitryNeurobiological modelsBrain circuitsConnectivity alterations