2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAlleles
2011
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
Drzezga A, Becker J, Van Dijk K, Sreenivasan A, Talukdar T, Sullivan C, Schultz A, Sepulcre J, Putcha D, Greve D, Johnson K, Sperling R. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 2011, 134: 1635-1646. PMID: 21490054, PMCID: PMC3102239, DOI: 10.1093/brain/awr066.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloidAniline CompoundsBenzothiazolesBrain MappingCerebral CortexCognition DisordersFemaleFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenPositron-Emission TomographyStatistics as TopicThiazolesConceptsWhole-brain connectivityDisruption of functional connectivityCortical hubsEarly functional consequencesMild cognitive impairmentFunctional connectivityAmyloid burdenCognitive impairmentNon-demented older individualsVoxel-based morphometry measuresAmyloid-positive patientsStructural magnetic resonanceDisruption of connectivityEmission tomographyCerebral glucose metabolismAlzheimer-type neurodegenerationAssociated with neuronal dysfunctionClinical Alzheimer's diseaseNon-demented subjectsCognitive symptomsIncreased amyloid burdenBrain regionsFunctional disconnectionNeuronal dysfunctionWhole-brain