Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis
Vélez de Mendizábal N, Carneiro J, Solé R, Goñi J, Bragard J, Martinez-Forero I, Martinez-Pasamar S, Sepulcre J, Torrealdea J, Bagnato F, Garcia-Ojalvo J, Villoslada P. Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis. BMC Systems Biology 2011, 5: 114. PMID: 21762505, PMCID: PMC3155504, DOI: 10.1186/1752-0509-5-114.Peer-Reviewed Original ResearchConceptsCross-regulationT cellsAutoimmune diseasesImmune systemMultiple sclerosisEffector T cellsRegulatory T cellsT cell memoryTissue damageEffects of such therapyPathogenesis of autoimmune diseasesT cell activationPredicting disease courseModulating effectorsBiological knowledgeMolecular mechanismsIrreversible tissue damageClinical relapseStochastic eventsRegulatory populationsCentral toleranceAutoimmune activityDisease courseNegative feedbackEffector