Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis
Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P. Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine 2005, 32: 111-116. PMID: 16246570, DOI: 10.1016/j.cyto.2005.08.005.Peer-Reviewed Original ResearchConceptsCD8+ T cellsRelapsing-remitting MST-cell phenotypeCD8+ lymphocytesDisability scoresIFN-gammaT cellsMultiple sclerosisPeripheral blood T-cell phenotypesPatients treated with interferon-betaHealthy controlsAssociated with disability scoresBlood T-cell phenotypesPeripheral T-cell phenotypePercentage of IFN-gammaEffects of immunomodulatory treatmentsIL-4 producing CD4Decrease of IFN-gammaRelapsing-remitting MS patientsRelapsing-remitting multiple sclerosisPathogenesis of multiple sclerosisCD4+ lymphocytesT cell populationsPresence of IFN-gammaPro-inflammatory profile