IL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis
Martinez‐Forero I, Garcia‐Munoz R, Martinez‐Pasamar S, Inoges S, de Cerio A, Palacios R, Sepulcre J, Moreno B, Gonzalez Z, Fernandez‐Diez B, Melero I, Bendandi M, Villoslada P. IL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. European Journal Of Immunology 2008, 38: 576-586. PMID: 18200504, DOI: 10.1002/eji.200737271.Peer-Reviewed Original ResearchConceptsTr1 cellsCD4(+) cellsIL-10R signalingIL-10MS patientsIL-10 stimulationIL-10RMultiple sclerosisIL-10R signaling pathwayIL-10RA geneCell type 1Anti-CD46 antibodiesExpression of cytokinesSTAT-3 phosphorylationInduced in vitroReal-time PCRCell therapyIL-10RASuppression assaysPatientsSuppressor activityType 1Baseline levelsCell functionSTAT-3