2022
Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
Marcos-Vidal L, Martínez-García M, Blas D, Navas-Sánchez F, Pretus C, Ramos-Quiroga J, Richarte V, Vilarroya Ó, Sepulcre J, Desco M, Carmona S. Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults. Journal Of Attention Disorders 2022, 26: 1563-1575. PMID: 35947490, DOI: 10.1177/10870547211031998.Peer-Reviewed Original ResearchConceptsIncreased local connectivityFunctional connectivityAtypical functional connectivity patternsAssociations with symptom severity scoresDistant functional connectivityDistribution of functional connectivityLocal functional connectivityFunctional connectivity patternsDecreased local connectivityADHD sampleNeuroimaging studiesAdult samplesDeficient integrationADHDSymptom severity scoresChild sampleInterference hypothesisLocal connectivityDelay hypothesisDMNConnectivity patternsHealthy controlsDistant connectionsAdultsDistant distributionLocal Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults
Marcos-Vidal L, Martínez-García M, de Blas D, Navas-Sánchez F, Pretus C, Ramos-Quiroga J, Richarte V, Vilarroya Ó, Sepulcre J, Desco M, Carmona S. Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults. Journal Of Attention Disorders 2022, 26: 1788-1801. PMID: 35684934, DOI: 10.1177/10870547221101646.Peer-Reviewed Original ResearchConceptsIncreased local connectivityFunctional connectivityAtypical functional connectivity patternsAssociations with symptom severity scoresDistant functional connectivityDistribution of functional connectivityLocal functional connectivityFunctional connectivity patternsDecreased local connectivityADHD sampleNeuroimaging studiesAdult samplesDeficient integrationADHDSymptom severity scoresChild sampleInterference hypothesisLocal connectivityDelay hypothesisDMNConnectivity patternsHealthy controlsDistant connectionsAdultsDistant distribution
2021
Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction
Costumero V, Negre P, Bustamante J, Fuentes‐Claramonte P, Adrián‐Ventura J, Palomar‐García M, Miró‐Padilla A, Llopis J, Sepulcre J, Barrós‐Loscertales A. Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction. Addiction Biology 2021, 26: e13072. PMID: 34137121, DOI: 10.1111/adb.13072.Peer-Reviewed Original ResearchConceptsCocaine use disorderFunctional magnetic resonance imagingLateral orbitofrontal cortexGraph theory measuresOrbitofrontal cortexCocaine use disorder individualsRight lateral orbitofrontal cortexResting state functional magnetic resonance imagingMiddle frontal cortexRight temporal poleLength of abstinenceSeverity of dependenceRight rolandic operculumHealthy controlsYears of educationVentral striatumIntellectual functioningLeft insulaLeft hippocampusFrontal cortexRolandic operculumTemporal poleTemporal cortexUse disorderNodal efficiency
2020
Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia
DuBois J, Mathotaarachchi S, Rousset O, Sziklas V, Sepulcre J, Guiot M, Hall J, Massarweh G, Soucy J, Rosa-Neto P, Kobayashi E. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. NeuroImage Clinical 2020, 29: 102552. PMID: 33401137, PMCID: PMC7787952, DOI: 10.1016/j.nicl.2020.102552.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasia patientsFocal cortical dysplasiaHealthy controlsCortical dysplasiaFCD patientsMetabotropic glutamate receptor type 5Contralateral hemisphereEpileptic activityPersistent epileptic activityDuration of epilepsySmall-world connectivityHigh centrality nodesMGluR5 availabilityIn vivo evidenceEpilepsy durationPatientsType 5Assess group differencesNetwork integrationMGluR5Binding potentialDysplasiaNetwork abnormalitiesGraph theoretical analysisEpilepsyNeurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade
Labayru G, Jimenez‐Marin A, Fernández E, Villanua J, Zulaica M, Cortes J, Díez I, Sepulcre J, de Munain A, Sistiaga A. Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade. Annals Of Clinical And Translational Neurology 2020, 7: 1802-1815. PMID: 32881379, PMCID: PMC7545612, DOI: 10.1002/acn3.51163.Peer-Reviewed Original ResearchConceptsVoxel Based MorphometryHealthy controlsFronto-subcortical networksPatterns of brain atrophyMultimodal integration networkExecutive function testsBrain structural abnormalitiesRegional brain volumesGM damageDM1 patientsNeuropsychological testsNeurodevelopmental originBrain changesPediatric onset patientsGM lossFrontal regionsVBM analysisWM volumeBrain abnormalitiesBrain volumeCognitive outcomesFollow-up MRI studiesHC groupYoung adulthoodImpairment assessment
2019
Distance disintegration delineates the brain connectivity failure of Alzheimer's disease
Costumero V, d'Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiology Of Aging 2019, 88: 51-60. PMID: 31941578, PMCID: PMC7085436, DOI: 10.1016/j.neurobiolaging.2019.12.005.Peer-Reviewed Original ResearchConceptsAssociated with lower global cognitionCognitive impairmentAlzheimer's diseaseBrain network dysfunctionAD-related changesMild cognitive impairmentFrontoparietal networkSalience networkMode networkStrength of connectionsNetwork-based investigationsGlobal cognitionNetwork dysfunctionAD-related conditionsBrain connectivityConnectivity changesCortical regionsConnection distanceInvestigation of brain connectivityAD spectrumVoxel levelHealthy controlsDistance of connectionBrainPathways of connectivityRegional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1
Labayru G, Diez I, Sepulcre J, Fernández E, Zulaica M, Cortés J, de Munain A, Sistiaga A. Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1. NeuroImage Clinical 2019, 24: 102078. PMID: 31795042, PMCID: PMC6861566, DOI: 10.1016/j.nicl.2019.102078.Peer-Reviewed Original ResearchConceptsGlobal gray matterDiffusion tensor imagingCTG expansion sizeSubcortical regionsWhite matter lesionsMyotonic dystrophy type 1Fractional anisotropyStructural brain signaturesBrain atrophyAssociated with cognitive impairmentStructural cerebral changesAssociation cortical regionsDegree of muscular impairmentMicrostructural WM abnormalitiesVoxel Based MorphometryWhite matterHealthy controlsDM1 patientsRegional brain atrophyType 1Global white matterIQ estimatesNeuropsychological profileGM reductionNeuropsychological scoresSensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder
Martínez K, Martínez-García M, Marcos-Vidal L, Janssen J, Castellanos F, Pretus C, Villarroya Ó, Pina-Camacho L, Díaz-Caneja C, Parellada M, Arango C, Desco M, Sepulcre J, Carmona S. Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 422-433. PMID: 31260788, DOI: 10.1016/j.jaac.2019.05.033.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAutism spectrum disorder groupHigh-functioning ASD individualsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsVineland Adaptive Behavior ScalesUnimodal regionsImpaired multisensory integrationAssociated with increased clinical severityMultisensory integration deficitsAdaptive Behavior ScalesFunctional connectivity analysisSocial Communication QuestionnaireSocial Responsiveness ScalePatterns of hyper-Connection integrityMultimodal sensory integrationFunctional dysconnectivityBrain systemsASD groupMode networkFronto-parietalHigh-functioning
2017
Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters
de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer's disease converters. Human Brain Mapping 2017, 38: 5905-5918. PMID: 28856799, PMCID: PMC5745046, DOI: 10.1002/hbm.23773.Peer-Reviewed Original ResearchBrief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level.
Duque P, Oltra-Cucarella J, Fernandez O, Sepulcre J, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple G. Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level. Revista De Neurologia 2017, 64: 97-104. PMID: 28128426, DOI: 10.33588/rn.6403.2016211.Peer-Reviewed Original ResearchConceptsNeuropsychological batteryTasks measuring working memoryNormative dataOriginal normative sampleInformation processing speedIdentified cognitive impairmentWorking memoryVerbal memoryNeuropsychological assessmentNormative sampleCognitive testsProcessing speedHealthy control groupStandard scoresCognitive impairmentMultiple sclerosisEducation levelHealthy controlsSex variableMemoryTaskHealthy volunteersRegression analysisBatteryControl group
2016
Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis
Agirrezabal I, Palacios R, Moreno B, Sepulcre J, Abernathy A, Saiz A, Llufriu S, Comabella M, Montalban X, Martinez A, Arteta D, Villoslada P. Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis. Multiple Sclerosis And Demyelinating Disorders 2016, 1: 7. DOI: 10.1186/s40893-016-0009-8.Peer-Reviewed Original ResearchRelapsing-remitting multiple sclerosisCaspase-2Gene OntologyTranscription factorsAnalysis of regulatory networksDisease activityLymphocyte activationAssociated with clinical disease activityGene tripletsRegulatory networksClinical disease activityCohort of MS patientsDNA arraysCo-regulationJASPAR databaseMAPKinase pathwayDEGsStable patientsProspective cohortDisability accumulationHealthy controlsClinical activityMS patientsTranscriptionGenes
2010
Lexical access changes in patients with multiple sclerosis: A two-year follow-up study
Sepulcre J, Peraita H, Goñi J, Arrondo G, Martincorena I, Duque B, de Mendizábal N, Masdeu J, Villoslada P. Lexical access changes in patients with multiple sclerosis: A two-year follow-up study. Journal Of Clinical And Experimental Neuropsychology 2010, 33: 169-175. PMID: 20835944, DOI: 10.1080/13803395.2010.499354.Peer-Reviewed Original ResearchConceptsConfrontation namingRetrieval of lexical informationSemantic verbal fluency taskPhonemic verbal fluency testVerbal fluency taskVerbal fluency testFluency taskTwo-year follow-up studyFluency testSwitching scoresLexical informationMultiple sclerosisMS patientsCommunication abilityHealthy controlsFollow-up studyNamesImpairmentYear follow-upConfrontationTaskScoresRetrievalSclerosisAbility
2009
Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis
Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P. Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal 2009, 15: 509-516. PMID: 19282416, DOI: 10.1177/1352458508101321.Peer-Reviewed Original ResearchConceptsCognitive impairmentBrain synchronyBRB-NCognitive functionBRB-N scoresEffect of MS lesionsEfficient cognitive processingBrain oscillatory activityHealthy controlsCentral nervous systemWhite matter tractsLong white matter tractsAuditory amplitude modulationExecutive functionVerbal memoryCognitive performanceDistant cortical areasBrain networksCognitive processesMultiple sclerosisBrain synchronizationYears of disease evolutionAuditory stimuliCortical areasBrain damageFractal dimension analysis of grey matter in multiple sclerosis
Esteban F, Sepulcre J, de Miras J, Navas J, de Mendizábal N, Goñi J, Quesada J, Bejarano B, Villoslada P. Fractal dimension analysis of grey matter in multiple sclerosis. Journal Of The Neurological Sciences 2009, 282: 67-71. PMID: 19167728, DOI: 10.1016/j.jns.2008.12.023.Peer-Reviewed Original ResearchConceptsGray matterMagnetic resonance imagingMultiple sclerosisVoxel-based morphometry approachExtensive grey matterAttack of MST1 MRI sequencesT2 lesion loadShorter disease durationWhite matter abnormalitiesGM abnormalitiesMorphometry approachGM morphologyGM atrophyMeasures of GMLong-term disabilityDisease durationHealthy controlsHuman brainMS patientsLesion loadPatientsAbnormalitiesResonance imagingMRI sequences
2007
Fractal dimension and white matter changes in multiple sclerosis
Esteban F, Sepulcre J, de Mendizábal N, Goñi J, Navas J, de Miras J, Bejarano B, Masdeu J, Villoslada P. Fractal dimension and white matter changes in multiple sclerosis. NeuroImage 2007, 36: 543-549. PMID: 17499522, DOI: 10.1016/j.neuroimage.2007.03.057.Peer-Reviewed Original ResearchConceptsMultiple sclerosisHealthy controlsCentrum semiovale levelWhite matterConventional MR imagingGray-white matter interfaceMR imaging sectionsVoxel-based morphometry approachCentral nervous systemConventional magnetic resonanceWhite matter changesWM abnormalitiesPatientsMR imagingMS lesionsNervous systemBrain white matterMatter changesMagnetic resonanceNAWMBrain WMBrains of patientsLesionsBrainEarly phase
2006
Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test
Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Multiple Sclerosis Journal 2006, 12: 187-195. PMID: 16629422, DOI: 10.1191/1352458506ms1258oa.Peer-Reviewed Original ResearchConceptsSymbol Digit Modalities TestBRB-N testsCognitive impairmentBRB-NHealthy controlsCognitive measuresPhysical disabilityMS patientsMultiple sclerosisModal testingImpairmentBriefIndividual testsCut-off valueDisabilityEducation levelRelapsing MSZ-scoreProgressive MSPatientsMonitoring patientsIllnessLevel of controlSclerosisStandard deviation
2005
Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis
Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P. Association between peripheral IFN-γ producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine 2005, 32: 111-116. PMID: 16246570, DOI: 10.1016/j.cyto.2005.08.005.Peer-Reviewed Original ResearchConceptsCD8+ T cellsRelapsing-remitting MST-cell phenotypeCD8+ lymphocytesDisability scoresIFN-gammaT cellsMultiple sclerosisPeripheral blood T-cell phenotypesPatients treated with interferon-betaHealthy controlsAssociated with disability scoresBlood T-cell phenotypesPeripheral T-cell phenotypePercentage of IFN-gammaEffects of immunomodulatory treatmentsIL-4 producing CD4Decrease of IFN-gammaRelapsing-remitting MS patientsRelapsing-remitting multiple sclerosisPathogenesis of multiple sclerosisCD4+ lymphocytesT cell populationsPresence of IFN-gammaPro-inflammatory profile