2021
Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
Orwig W, Diez I, Bueichekú E, Vannini P, Beaty R, Sepulcre J. Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain. Frontiers In Human Neuroscience 2021, 15: 694274. PMID: 34381343, PMCID: PMC8350487, DOI: 10.3389/fnhum.2021.694274.Peer-Reviewed Original ResearchSynaptic plasticityOrganization of brain networksFunctional neuroimaging dataHuman brainCreative abilitiesBrain networksFunctional connectivityNeuroimaging phenotypesGraph theory approachNeuroimaging dataNeural plasticityCortical networksBiological basisCortical distributionConnectivity mapsDistributed connectivityCreative thinkingDistribution of genesGene expression distributionSets of genesGene expression informationBrainSynaptic assemblyGene expression profilesNeuroimaging
2020
Early-life trauma endophenotypes and brain circuit–gene expression relationships in functional neurological (conversion) disorder
Diez I, Larson A, Nakhate V, Dunn E, Fricchione G, Nicholson T, Sepulcre J, Perez D. Early-life trauma endophenotypes and brain circuit–gene expression relationships in functional neurological (conversion) disorder. Molecular Psychiatry 2020, 26: 3817-3828. PMID: 32051548, PMCID: PMC7423688, DOI: 10.1038/s41380-020-0665-0.Peer-Reviewed Original ResearchConceptsEarly-life maltreatmentAllen Human Brain AtlasPhysical abusePathophysiology of FNDFunctional connectivity architectureHuman Brain AtlasCognitive controlPsychiatric controlsMotor FNDAbuse severityLimbic/paralimbic areasNeuropsychiatric conditionsIndividual differencesPhysical neglectFunctional connectivitySubtype effectsGraph theory approachConnectivity profilesLeft-lateral structuresExploratory analysisCell motility genesEndophenotypesMotor cortexMotor phenotypeRight‐lateral structure