Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis
Agirrezabal I, Palacios R, Moreno B, Sepulcre J, Abernathy A, Saiz A, Llufriu S, Comabella M, Montalban X, Martinez A, Arteta D, Villoslada P. Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis. Multiple Sclerosis And Demyelinating Disorders 2016, 1: 7. DOI: 10.1186/s40893-016-0009-8.Peer-Reviewed Original ResearchRelapsing-remitting multiple sclerosisCaspase-2Gene OntologyTranscription factorsAnalysis of regulatory networksDisease activityLymphocyte activationAssociated with clinical disease activityGene tripletsRegulatory networksClinical disease activityCohort of MS patientsDNA arraysCo-regulationJASPAR databaseMAPKinase pathwayDEGsStable patientsProspective cohortDisability accumulationHealthy controlsClinical activityMS patientsTranscriptionGenes