2019
Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder
Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina J, Dickerson B, Keshavan M, LaFrance W, Sepulcre J, Perez D. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. Journal Of Neurology Neurosurgery & Psychiatry 2019, 90: 929. PMID: 30850473, PMCID: PMC6625895, DOI: 10.1136/jnnp-2018-319657.Peer-Reviewed Original ResearchConceptsFunctional neurological disorderLeft anterior insulaRight anterior insulaAnterior insulaSymptom severityWithin-group analysisPathophysiology of functional neurological disorderFunctional neurological disorder cohortsMotor functional neurological disorderRight laterobasal amygdalaMultimodal integration networkBilateral posterior insulaMiddle cingulate cortexMultimodal integration areasLaterobasal amygdalaDisorder subscaleCentromedial amygdalaCingulate cortexInteroceptive processingAffective disturbancesPatient-reported symptom severityPosterior insulaWithin-group associationsAmygdalar nucleiBetween-group differences
2017
Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder
Perez D, Williams B, Matin N, LaFrance W, Costumero-Ramos V, Fricchione G, Sepulcre J, Keshavan M, Dickerson B. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. Journal Of Neurology Neurosurgery & Psychiatry 2017, 88: 1052. PMID: 28844071, DOI: 10.1136/jnnp-2017-316359.Peer-Reviewed Original ResearchConceptsPathophysiology of functional neurological disorderFunctional neurological disorderInsular volumeTrait anxietyWithin-group analysisSalience networkAmygdalar volumeMental healthVolumetric differencesFunctional neurological disorder cohortsEmotional problemsSevere physical health impairmentMotor FND subtypesSecondary within-group analysisRight amygdalar volumeElevated trait anxietySalience network regionsPhysical health impairmentAssociated with mental healthNeurological symptom severityHealth statusAssociated with role limitationsImpaired mental healthAffective symptomsWell-being deficits