2022
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease
Guzmán-Vélez E, Diez I, Schoemaker D, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller J, Baena A, Sperling R, Johnson K, Lopera F, Sepulcre J, Quiroz Y. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2113641119. PMID: 35380901, PMCID: PMC9169643, DOI: 10.1073/pnas.2113641119.Peer-Reviewed Original ResearchConceptsDefault-mode networkFunctional connectivitySalience networkRetrospenial cortexFunctional segregationPosterior default-mode networkAmyloid-bDefault-mode network regionsHigher-order cognitive functionsEarly-onset AD dementiaTau pathologyMedial prefrontal cortexAnterior cingulate cortexDisrupting neural communicationGraph-based network analysisBrain functional architectureMedial temporal regionsFunctional networksAlzheimer's diseaseBrain functional connectivityPreclinical Alzheimer's diseasePrefrontal cortexTau burdenCingulate cortexEpisodic memory
2021
A reachable probability approach for the analysis of spatio-temporal dynamics in the human functional network
Gao Q, Xiang Y, Zhang J, Luo N, Liang M, Gong L, Yu J, Cui Q, Sepulcre J, Chen H. A reachable probability approach for the analysis of spatio-temporal dynamics in the human functional network. NeuroImage 2021, 243: 118497. PMID: 34428571, DOI: 10.1016/j.neuroimage.2021.118497.Peer-Reviewed Original ResearchConceptsHuman brainBrain network systemsBrain functional systemsHierarchical functional organizationPrimary sensory cortexHuman functional networkMode networkMultisensory integration regionsPerceptual modalitiesMultisensory integrationSensory cortexNetwork systemAnalysis of spatio-temporal dynamicsFunctional networksTransition probabilitiesNeuronal circuitsDynamic architectureFunctional systemsFunctional organizationLocalize functional regionsDifferential patternConnectional organizationConnection structureProbability approachNetwork steady state
2019
Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder
Pretus C, Marcos‐Vidal L, Martínez‐García M, Picado M, Ramos‐Quiroga J, Richarte V, Castellanos F, Sepulcre J, Desco M, Vilarroya Ó, Carmona S. Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder. Human Brain Mapping 2019, 40: 4645-4656. PMID: 31322305, PMCID: PMC6865796, DOI: 10.1002/hbm.24727.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional connectivitySensory regionsNeural hubCognitive functionResting-state functional magnetic resonance imagingAttention deficit hyperactivity disorderFunctional magnetic resonance imagingSeed regionPatterns of functional connectivityDefault-mode networkDeficit hyperactivity disorderFunctional networksPrimary sensory regionsFunctional overconnectivityAttention-deficit/hyperactivityNeuroimaging studiesMode networkHyperactivity disorderLow connectivity degreeRs-fMRIPattern of alterationsSeverity ScaleSensory inputMagnetic resonance imaging
2018
Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder
Marcos‐Vidal L, Martínez‐García M, Pretus C, Garcia‐Garcia D, Martínez K, Janssen J, Vilarroya O, Castellanos F, Desco M, Sepulcre J, Carmona S. Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder. Human Brain Mapping 2018, 39: 2442-2454. PMID: 29473262, PMCID: PMC6866394, DOI: 10.1002/hbm.24013.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderND childrenFunctional connectivityAttention-deficit/hyperactivityFronto-parietalGroup differencesSomatomotor areasAttention-deficit/hyperactivity disorder symptomsSeverity of ADHD symptomsAttention-deficit/hyperactivity disorder diagnosisAtypical functional connectivityMaturational lag hypothesisVentral attention networkAtypical developmental patternPotential group differencesIncreased local connectivityFunctional networksHuman brain changesMultiple brain regionsLocal functional connectivityImmature functional stateBrain functional networksSeverity of clinical symptomsADHD symptomsSomatomotor regions
2016
Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease
Sepulcre J, Masdeu J. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods In Molecular Biology 2016, 1303: 509-519. PMID: 26235088, DOI: 10.1007/978-1-4939-2627-5_31.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional magnetic resonance imagingAlzheimer's diseaseEarly stages of Alzheimer's diseaseOxygen level-dependentMagnetic resonance imagingStages of Alzheimer's diseaseNeurobiological changesStructural neuroimagingBrain networksBrain regionsBrains of patientsPostmortem studiesLevel-dependentNeurobiology of ADFunctional networksPostmortem dataBrainQuiet wakefulnessTau depositionResonance imagingTherapeutic interventionsNetwork propertiesNeurobiologyNeuroimaging
2012
Network assemblies in the functional brain
Sepulcre J, Sabuncu M, Johnson K. Network assemblies in the functional brain. Current Opinion In Neurology 2012, 25: 384-391. PMID: 22766721, PMCID: PMC3471530, DOI: 10.1097/wco.0b013e328355a8e8.Peer-Reviewed Original Research