2023
Creativity at rest: Exploring functional network connectivity of creative experts
Orwig W, Setton R, Diez I, Bueichekú E, Meyer M, Tamir D, Sepulcre J, Schacter D. Creativity at rest: Exploring functional network connectivity of creative experts. Network Neuroscience 2023, 7: 1022-1033. PMID: 37781148, PMCID: PMC10473280, DOI: 10.1162/netn_a_00317.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFunctional connectivityReduced connectivityAssociated with creative abilityReplicate prior findingsVisual cortexBrain network organizationStudies of functional connectivityFunctional brain connectivityLateral visual cortexFunctional network connectivityNeuroscience of creativityComplex brain processesNeuroimaging studiesGeneration of novel ideasBrain processesBrain connectivityConnectivity profilesCreative performanceCreative behaviorCortexPrimary visual cortexMagnetic resonance imagingNetwork organizationNegative association
2021
Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction
Costumero V, Negre P, Bustamante J, Fuentes‐Claramonte P, Adrián‐Ventura J, Palomar‐García M, Miró‐Padilla A, Llopis J, Sepulcre J, Barrós‐Loscertales A. Distance disintegration characterizes node‐level topological dysfunctions in cocaine addiction. Addiction Biology 2021, 26: e13072. PMID: 34137121, DOI: 10.1111/adb.13072.Peer-Reviewed Original ResearchConceptsCocaine use disorderFunctional magnetic resonance imagingLateral orbitofrontal cortexGraph theory measuresOrbitofrontal cortexCocaine use disorder individualsRight lateral orbitofrontal cortexResting state functional magnetic resonance imagingMiddle frontal cortexRight temporal poleLength of abstinenceSeverity of dependenceRight rolandic operculumHealthy controlsYears of educationVentral striatumIntellectual functioningLeft insulaLeft hippocampusFrontal cortexRolandic operculumTemporal poleTemporal cortexUse disorderNodal efficiency
2019
Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults
Uquillas F, Jacobs H, Schultz A, Hanseeuw B, Buckley R, Sepulcre J, Pascual-Leone A, Donovan N, Johnson K, Sperling R, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cerebral Cortex 2019, 30: 1974-1983. PMID: 31696223, PMCID: PMC7132950, DOI: 10.1093/cercor/bhz217.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCognitively unimpaired older adultsMetamemory processesMemory performanceOlder adultsMidline regionVentromedial prefrontal cortexFunctional magnetic resonance imaging signalsHarvard Aging Brain StudyJudgments of learningAging Brain StudyAlzheimer's diseaseMemory successPrefrontal cortexAssociated with overestimationNeural substratesTau pathologyBilateral hippocampiBrain studiesJOLsCohort of older adultsMagnetic resonance imagingCognitionAD dementiaTau depositionMulti-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury
Wooten D, Ortiz-Terán L, Zubcevik N, Zhang X, Huang C, Sepulcre J, Atassi N, Johnson K, Zafonte R, Fakhri G. Multi-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury. Journal Of Neurotrauma 2019, 36: 3233-3243. PMID: 31210098, PMCID: PMC6857466, DOI: 10.1089/neu.2018.6178.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryTraumatic brain injury subjectsDistribution volume ratioWhite matter integrityFunctional connectivityDiffusion tensor imagingPositron emission tomographyTBI subjectsResting-state functional magnetic resonance imagingResting state functional connectivityFunctional magnetic resonance imagingFractional anisotropyDecreased white matter integrityGroup of TBI subjectsIncreased functional connectivityFunctional MRI resultsGraph theory metricsBrain injuryLiving human brainMagnetic resonance imagingNoninvasive neuroimaging techniquesBrain regionsFunctional MRINeuroimaging techniquesDiffusion tractography imagingStepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder
Pretus C, Marcos‐Vidal L, Martínez‐García M, Picado M, Ramos‐Quiroga J, Richarte V, Castellanos F, Sepulcre J, Desco M, Vilarroya Ó, Carmona S. Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder. Human Brain Mapping 2019, 40: 4645-4656. PMID: 31322305, PMCID: PMC6865796, DOI: 10.1002/hbm.24727.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional connectivitySensory regionsNeural hubCognitive functionResting-state functional magnetic resonance imagingAttention deficit hyperactivity disorderFunctional magnetic resonance imagingSeed regionPatterns of functional connectivityDefault-mode networkDeficit hyperactivity disorderFunctional networksPrimary sensory regionsFunctional overconnectivityAttention-deficit/hyperactivityNeuroimaging studiesMode networkHyperactivity disorderLow connectivity degreeRs-fMRIPattern of alterationsSeverity ScaleSensory inputMagnetic resonance imagingSensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder
Martínez K, Martínez-García M, Marcos-Vidal L, Janssen J, Castellanos F, Pretus C, Villarroya Ó, Pina-Camacho L, Díaz-Caneja C, Parellada M, Arango C, Desco M, Sepulcre J, Carmona S. Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 422-433. PMID: 31260788, DOI: 10.1016/j.jaac.2019.05.033.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAutism spectrum disorder groupHigh-functioning ASD individualsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsVineland Adaptive Behavior ScalesUnimodal regionsImpaired multisensory integrationAssociated with increased clinical severityMultisensory integration deficitsAdaptive Behavior ScalesFunctional connectivity analysisSocial Communication QuestionnaireSocial Responsiveness ScalePatterns of hyper-Connection integrityMultimodal sensory integrationFunctional dysconnectivityBrain systemsASD groupMode networkFronto-parietalHigh-functioning
2016
Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms
Beucke J, Sepulcre J, Buhlmann U, Kathmann N, Moody T, Feusner J. Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. European Neuropsychopharmacology 2016, 26: 1657-1666. PMID: 27514293, PMCID: PMC5316290, DOI: 10.1016/j.euroneuro.2016.04.011.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderBody dysmorphic disorderFunctional magnetic resonance imagingOrbitofrontal cortexDysmorphic disorderSymptom severityFunctional connectivityYale-Brown Obsessive-Compulsive ScaleResting-state functional connectivityDegree connectivityFace processing taskObsessive-Compulsive ScaleBrain-behavior associationsDegree of functional connectivityCompulsive symptomsObsessive-compulsiveAmygdalar connectivityCompulsive behaviorsObsessive thoughtsBrain hyperactivitySymptom provocationDistant connectionsBrain areasDiagnostic groupsBasal gangliaAdvanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease
Sepulcre J, Masdeu J. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods In Molecular Biology 2016, 1303: 509-519. PMID: 26235088, DOI: 10.1007/978-1-4939-2627-5_31.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional magnetic resonance imagingAlzheimer's diseaseEarly stages of Alzheimer's diseaseOxygen level-dependentMagnetic resonance imagingStages of Alzheimer's diseaseNeurobiological changesStructural neuroimagingBrain networksBrain regionsBrains of patientsPostmortem studiesLevel-dependentNeurobiology of ADFunctional networksPostmortem dataBrainQuiet wakefulnessTau depositionResonance imagingTherapeutic interventionsNetwork propertiesNeurobiologyNeuroimaging
2014
Default mode network subsystem alterations in obsessive–compulsive disorder
Beucke J, Sepulcre J, Eldaief M, Sebold M, Kathmann N, Kaufmann C. Default mode network subsystem alterations in obsessive–compulsive disorder. The British Journal Of Psychiatry 2014, 205: 376-382. PMID: 25257066, DOI: 10.1192/bjp.bp.113.137380.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderAssociated with self-referential processingModels of obsessive-compulsive disorderSeed-based resting-state functional connectivityObsessive-compulsive disorder groupHistory of affective disorderResting-state functional connectivityFunctional magnetic resonance imagingSelf-referential processingCorticostriatal brain regionsLife-time historyMode network componentsNeurobiological modelsAffective disordersBrain regionsFunctional connectivityReduced connectivityNeural systemsMedical statusAttention networkDisordered backgroundMagnetic resonance imagingDisordersNetwork integration
2013
Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Beucke J, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder. JAMA Psychiatry 2013, 70: 619-629. PMID: 23740050, DOI: 10.1001/jamapsychiatry.2013.173.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderOrbitofrontal cortexUnmedicated patientsAntidepressant medicationBasal gangliaSymptom severityObsessive-compulsive disorder symptom severityConsistent with neurobiological modelsTreated with antidepressant medicationResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingOCD symptom severityReduced local connectivityLocal functional connectivityBrain network propertiesDegree connectivityStatistical parametric mappingVentral striatumCase-control cross-sectional studyCorticostriatal circuitryNeurobiological modelsBrain circuitsConnectivity alterations