2024
Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption
d’Oleire Uquillas F, Sefik E, Li B, Trotter M, Steele K, Seidlitz J, Gesue R, Latif M, Fasulo T, Zhang V, Kislin M, Verpeut J, Cohen J, Sepulcre J, Wang S, Gomez J. Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption. Molecular Psychiatry 2024, 1-15. PMID: 39390225, DOI: 10.1038/s41380-024-02769-1.Peer-Reviewed Original ResearchAutism spectrum disorderNeurotypical childrenFunctional connectivityMultimodal evidenceFunctional connectivity analysisModel of autismCerebro-cerebellar pathwayAtypical connectivitySpectrum disorderConnectivity analysisEarly adolescenceASD childrenCerebellar influenceBehavioral developmentNeurodevelopmental disordersFunctional-structural relationshipsCerebellar structuresAutismYoung childhoodLiving brainCerebellumFunctional synchronizationThalamusSignificant lateralizationCerebral cortex
2019
Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder
Martínez K, Martínez-García M, Marcos-Vidal L, Janssen J, Castellanos F, Pretus C, Villarroya Ó, Pina-Camacho L, Díaz-Caneja C, Parellada M, Arango C, Desco M, Sepulcre J, Carmona S. Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 422-433. PMID: 31260788, DOI: 10.1016/j.jaac.2019.05.033.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAutism spectrum disorder groupHigh-functioning ASD individualsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsVineland Adaptive Behavior ScalesUnimodal regionsImpaired multisensory integrationAssociated with increased clinical severityMultisensory integration deficitsAdaptive Behavior ScalesFunctional connectivity analysisSocial Communication QuestionnaireSocial Responsiveness ScalePatterns of hyper-Connection integrityMultimodal sensory integrationFunctional dysconnectivityBrain systemsASD groupMode networkFronto-parietalHigh-functioning
2017
Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children
Ortiz-Terán L, Diez I, Ortiz T, Perez D, Aragón J, Costumero V, Pascual-Leone A, Fakhri G, Sepulcre J. Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 6830-6835. PMID: 28607055, PMCID: PMC5495230, DOI: 10.1073/pnas.1619121114.Peer-Reviewed Original ResearchConceptsBlind childrenFunctional connectivity analysisMultisensory integration areasSensory deprivationFunctional connectivity relationshipsProtein gene familyNetwork connectivity profilesPrimary sensory cortexSystems-level analysisNeuroplastic adaptationsMultisensory cortexFunctional connectivityConnectivity analysisHuman neuroplasticityConnectivity changesGene expression profilesConnectivity profilesNeural reorganizationSensory cortexGene familySighted controlsHuman brainCortexBiological basisGenetic underpinnings
2016
Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices
Ortiz-Terán L, Ortiz T, Perez D, Aragón J, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Frontiers In Systems Neuroscience 2016, 10: 61. PMID: 27458350, PMCID: PMC4937754, DOI: 10.3389/fnsys.2016.00061.Peer-Reviewed Original ResearchSuperior parietal cortexLateral occipital cortexLate-onset blindnessTemporoparietal junctionVentral premotorNeuroplastic changesGroup of sighted controlsDistributed neural systemVisual processing regionsBlind individualsFunctional connectivity analysisMultimodal integration regionsCross-modal neuroplasticityFunctional network alterationsInvestigate functional reorganizationHeteromodal cortexNeuroimaging investigationsParietal cortexBrain networksCross-modal plasticityAssociation cortexOccipital cortexConnectivity analysisNeuroplastic alterationsProcessing regions