Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways
Sepulcre J, Masdeu J, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, Villoslada P. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Multiple Sclerosis Journal 2009, 15: 337-344. PMID: 18987107, DOI: 10.1177/1352458508098373.Peer-Reviewed Original ResearchConceptsMultiple sclerosisGray matter atrophyWhite matter lesion locationFatigue scoresLocation of white matter lesionsModified Fatigue Impact ScaleWhite matter lesionsMagnetic resonance imagingVoxel-based morphometry methodFatigue Impact ScaleAtrophy degreeWhite matter regionsMS-related fatigueBilateral middle frontal gyriSymptoms of fatigueLeft superior frontal gyrusLesion loadCognitive/attentional processesPatients' qualityLesion locationResonance imagingSuperior frontal gyrusImpact ScaleLesionsMiddle frontal gyri