2022
Connectomic-genetic signatures in the cerebral small vessel disease
Gutiérrez-Zúñiga R, Diez I, Bueichekú E, Kim C, Orwig W, Montal V, Fuentes B, Díez-Tejedor E, Fernández M, Sepulcre J. Connectomic-genetic signatures in the cerebral small vessel disease. Neurobiology Of Disease 2022, 167: 105671. PMID: 35231560, PMCID: PMC8957615, DOI: 10.1016/j.nbd.2022.105671.Peer-Reviewed Original Research
2018
Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology
Grothe M, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel S, Initiative A. Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology. Brain 2018, 141: 2755-2771. PMID: 30016411, PMCID: PMC6113636, DOI: 10.1093/brain/awy189.Peer-Reviewed Original ResearchConceptsRegional gene expression profilesGene expression profilesAlzheimer's disease pathologyExpression profilesPathophysiological mechanism of Alzheimer's diseaseDisease pathologyAlzheimer's diseaseAmyloid depositsExpression levelsMechanisms of Alzheimer's diseaseHuman brain transcriptomeGene set enrichment analysisTau kinasesAlzheimer's Disease Neuroimaging InitiativeMicroarray measurementsTau proteinMAPT expressionAllen Brain AtlasGene setsAmyloid precursorBrain transcriptomeRas-ERKNeurofibrillary degenerationRegionally selective vulnerabilityMitochondrial respiration